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Tbio
F13B
Coagulation factor XIII B chain

Protein Summary
Description
The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367412
  • ENSP00000356382
  • ENSG00000143278

Symbol
  • FXIIIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.75
cell type or tissue
0.65
disease
0.62
biological term
0.5
disease perturbation
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.34   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.34   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
FGA
Tbio
Novelty:  0.00107227
Score:  0.989
Data Source:  STRINGDB
F13A1
Tchem
Family:  Enzyme
Novelty:  0.00629746
Score:  0.985
Data Source:  Reactome,STRINGDB
FGB
Tbio
Novelty:  0.00437751
Score:  0.981
Data Source:  STRINGDB
FGG
Tbio
Novelty:  0.00404457
Score:  0.98
Data Source:  STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
Score:  0.976
Data Source:  STRINGDB
SERPIND1
Tbio
Novelty:  0.00120897
Score:  0.942
Data Source:  STRINGDB
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.941
Data Source:  Reactome,STRINGDB
SERPINA5
Tbio
Family:  Enzyme
Novelty:  0.00152504
Score:  0.94
Data Source:  STRINGDB
PROC
Tchem
Family:  Enzyme
Novelty:  0.00440723
Score:  0.935
Data Source:  STRINGDB
F10
Tclin
Family:  Enzyme
Novelty:  0.00063008
Score:  0.925
Data Source:  STRINGDB
Pathways (9)
Common Pathway of Fibrin Clot Formation (R-HSA-140875)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Common Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.7
96.3
blood protein measurement
2
2
1
1.8
87.4
complement factor H-related protein 1 measurement
1
2
0
14.4
82.7
sex hormone-binding globulin measurement
2
1
2
69.2
complement factor H-related protein 5 measurement
1
1
1
51.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
96.3
blood protein measurement
1
1.8
87.4
complement factor H-related protein 1 measurement
0
14.4
82.7
sex hormone-binding globulin measurement
2
69.2
complement factor H-related protein 5 measurement
1
51.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coagulation factor XIII B chain
VGNC:7403
735857
Macaque
coagulation factor XIII B chain
711237
Mouse
MGI:88379
14060
Rat
RGD:1311668
289055
Dog
coagulation factor XIII B chain
VGNC:40546
490261
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coagulation factor XIII B chain
Macaque
coagulation factor XIII B chain
Mouse
Rat
Dog
coagulation factor XIII B chain
Publication Statistics
PubMed Score 196.34
PubMed score by year
PubTator Score 155.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title