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Tchem
F12
Coagulation factor XII

Protein Summary
Description
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallik ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253496
  • ENSP00000253496
  • ENSG00000131187

Symbol
  • HAF
  • HAE3
  • HAEX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.97
biological term
0.8
disease
0.69
biological process
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 684.47   (req: < 5)
Gene RIFs: 129   (req: <= 3)
Antibodies: 656   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 684.47   (req: >= 5)
Gene RIFs: 129   (req: > 3)
Antibodies: 656   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 85
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (85)
US8598206, Table 6, 24
Rendered image for US8598206, Table 6, 24
CHEMBL4634303
Rendered image for CHEMBL4634303
CHEMBL4646710
Rendered image for CHEMBL4646710
CHEMBL4640835
Rendered image for CHEMBL4640835
CHEMBL3660184
Rendered image for CHEMBL3660184
CHEMBL3660176
Rendered image for CHEMBL3660176
US8598206, Table 6, 15
Rendered image for US8598206, Table 6, 15
US8598206, Table 6, 8
Rendered image for US8598206, Table 6, 8
SID24823247
Rendered image for SID24823247
US8598206, Table 6, 14
Rendered image for US8598206, Table 6, 14
Protein-Protein Interactions (105)
ANKRD40
Tdark
Novelty:  1.06633958
p_int:  0.862601606
p_ni:  0.137398394
Score:  0.209
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.797326936
p_ni:  0.202673064
Score:  0.176
Data Source:  BioPlex,STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.985
Data Source:  Reactome,STRINGDB
KLKB1
Tclin
Family:  Enzyme
Novelty:  0.00109438
Score:  0.974
Data Source:  Reactome,STRINGDB
SERPING1
Tbio
Family:  Enzyme
Novelty:  0.00068448
Score:  0.974
Data Source:  Reactome,STRINGDB
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
Score:  0.961
Data Source:  STRINGDB
F11
Tchem
Family:  Enzyme
Novelty:  0.00169618
Score:  0.959
Data Source:  Reactome,STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
Score:  0.958
Data Source:  STRINGDB
GP1BA
Tbio
Novelty:  0.00138736
Score:  0.957
Data Source:  Reactome,STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
Score:  0.928
Data Source:  Reactome,STRINGDB
Pathways (8)
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Intrinsic Pathway of Fibrin Clot Formation
Name
Explore in Pharos
Explore in Source
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Intrinsic Pathway of Fibrin Clot Formation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (57)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
8
11
15.2
99.3
creatinine measurement
5
6
7
97
partial thromboplastin time
2
2
2
96.1
hematocrit
5
5
5
96.1
hemoglobin measurement
4
4
4
94.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
11
15.2
99.3
creatinine measurement
7
97
partial thromboplastin time
2
96.1
hematocrit
5
96.1
hemoglobin measurement
4
94.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coagulation factor XII
VGNC:6868
462304
Macaque
coagulation factor XII
699875
Mouse
MGI:1891012
58992
Rat
RGD:1359175
306761
Horse
coagulation factor XII
VGNC:17754
100068589
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coagulation factor XII
Macaque
coagulation factor XII
Mouse
Rat
Horse
coagulation factor XII
Publication Statistics
PubMed Score 684.47
PubMed score by year
PubTator Score 919.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title