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Tchem
F11
Coagulation factor XI

Protein Summary
Description
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264692
  • ENSP00000264692
  • ENSG00000088926
  • ENST00000403665
  • ENSP00000384957

Symbol
  • FXI
  • PTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological term
0.84
molecular function
0.73
gene perturbation
0.63
disease
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 653.55   (req: < 5)
Gene RIFs: 147   (req: <= 3)
Antibodies: 431   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 653.55   (req: >= 5)
Gene RIFs: 147   (req: > 3)
Antibodies: 431   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 727
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (96)
PRCC
Tbio
Novelty:  0.00836323
p_int:  0.99918109
p_ni:  0.000805081
p_wrong:  0.000013829
Score:  0.26
Data Source:  BioPlex,STRINGDB
APP
Tchem
Novelty:  0.00008964
p_int:  0.954623545
p_ni:  0.045376455
Score:  0.423
Data Source:  BioPlex,STRINGDB
CRELD2
Tbio
Novelty:  0.09438775
p_int:  0.886266509
p_ni:  0.113733476
p_wrong:  1.5e-8
Score:  0.282
Data Source:  BioPlex,STRINGDB
N4BP2L2
Tbio
Novelty:  0.24527466
p_int:  0.756662129
p_ni:  0.239912216
p_wrong:  0.003425655
Score:  0.189
Data Source:  BioPlex,STRINGDB
F8
Tbio
Novelty:  0.0002287
Score:  0.988
Data Source:  STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
Score:  0.987
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.982
Data Source:  STRINGDB
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.968
Data Source:  Reactome,STRINGDB
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
Score:  0.966
Data Source:  Reactome,STRINGDB
F12
Tchem
Family:  Enzyme
Novelty:  0.00143881
Score:  0.959
Data Source:  Reactome,STRINGDB
Pathways (6)
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Intrinsic Pathway of Fibrin Clot Formation
Name
Explore in Pharos
Explore in Source
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Intrinsic Pathway of Fibrin Clot Formation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
7
1
1.2
99
blood metabolite measurement
2
3
3
95.6
partial thromboplastin time
1
3
3
92.2
serum metabolite measurement
2
2
3
89
factor XI measurement
1
1
1
88.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.2
99
blood metabolite measurement
3
95.6
partial thromboplastin time
3
92.2
serum metabolite measurement
3
89
factor XI measurement
1
88.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coagulation factor XI
VGNC:2036
461643
Macaque
coagulation factor XI
702117
Mouse
MGI:99481
109821
Dog
coagulation factor XI
VGNC:40544
475623
Horse
coagulation factor XI
VGNC:17753
100056603
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coagulation factor XI
Macaque
coagulation factor XI
Mouse
Dog
coagulation factor XI
Horse
coagulation factor XI
Publication Statistics
PubMed Score 653.55
PubMed score by year
PubTator Score 555.54
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title