Protein Summary
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in facto ...more
- ENST00000375559
- ENSP00000364709
- ENSG00000126218
- FX
- FXA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
biological term | 0.99 | ||
drug | 0.99 | ||
kinase perturbation | 0.93 | ||
transcription factor perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1748.45 (req: < 5)
Gene RIFs: 231 (req: <= 3)
Antibodies: 593 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1748.45 (req: >= 5)
Gene RIFs: 231 (req: > 3)
Antibodies: 593 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4038
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (5)
Active Ligands (4038)
Protein-Protein Interactions (97)
PIP4P2
Family: Enzyme
Novelty: 0.94294105
p_int: 0.99985562
p_ni: 0.000041382
p_wrong: 0.000102999
Data Source: BioPlex
Nearest Tclin Targets
Pathways (19)
Reactome (12)
KEGG (1)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Common Pathway of Fibrin Clot Formation | ||||
Reactome | Extrinsic Pathway of Fibrin Clot Formation | ||||
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Reactome | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Reactome | Gamma-carboxylation of protein precursors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Common Pathway of Fibrin Clot Formation | ||||
Extrinsic Pathway of Fibrin Clot Formation | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Gamma-carboxylation of protein precursors | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (6)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
factor VII measurement | 2 | 8 | 8 | 99.7 | |||||
prothrombin time measurement | 2 | 5 | 5 | 99 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 76.5 | |||||
reticulocyte measurement | 3 | 3 | 3 | 73.2 | |||||
mean corpuscular volume | 1 | 1 | 1 | 59 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
factor VII measurement | 8 | 99.7 | |||||
prothrombin time measurement | 5 | 99 | |||||
mean corpuscular hemoglobin concentration | 1 | 76.5 | |||||
reticulocyte measurement | 3 | 73.2 | |||||
mean corpuscular volume | 1 | 59 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | coagulation factor X | VGNC:7830 | 107968009 | |||||
Macaque | coagulation factor X | 714132 | ||||||
Mouse | MGI:103107 | 14058 | ||||||
Rat | RGD:61850 | 29243 | ||||||
Dog | coagulation factor X | VGNC:40543 | 476993 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | coagulation factor X | |||||
Macaque | coagulation factor X | |||||
Mouse | ||||||
Rat | ||||||
Dog | coagulation factor X | |||||
Publication Statistics
PubMed Score 1748.45
PubMed score by year
PubTator Score 3277.05
PubTator score by year
Related Publications
Text Mined References (290)
GeneRif Annotations (231)
Items per page:
0 of 0
PMID | Year | Title |
|---|