Protein Summary
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
- ENST00000337147
- ENSP00000338934
- ENSG00000092820
- ENST00000367075
- ENSP00000356042
- VIL2
- CVL
- CVIL
- VIL2
- HEL-S-105
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
hub protein | 1 | ||
kinase | 1 | ||
protein domain | 1 | ||
disease perturbation | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 853.48 (req: < 5)
Gene RIFs: 333 (req: <= 3)
Antibodies: 1346 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 853.48 (req: >= 5)
Gene RIFs: 333 (req: > 3)
Antibodies: 1346 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 53
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (291)
RDX
Novelty: 0.00236103
p_int: 0.999995925
p_ni: 0.000004075
Score: 0.938
Data Source: BioPlex,STRINGDB
ZNF622
Novelty: 0.26258288
p_int: 0.999784924
p_ni: 0.000203892
p_wrong: 0.000011185
Data Source: BioPlex
MSN
Novelty: 0.00178275
p_int: 0.999650763
p_ni: 0.000349237
Score: 0.948
Data Source: BioPlex,STRINGDB
MISP
Novelty: 0.02030151
p_int: 0.957822795
p_ni: 0.042177205
Score: 0.297
Data Source: BioPlex,STRINGDB
BCR
Novelty: 0.00127709
p_int: 0.863788225
p_ni: 0.13621177
p_wrong: 4e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
SLC9A3R2
Family: Transporter
Novelty: 0.01401705
p_int: 0.856616328
p_ni: 0.143383672
Score: 0.939
Data Source: BioPlex,STRINGDB
TSPAN33
Novelty: 0.17463296
p_int: 0.778813037
p_ni: 0.221186963
Score: 0.417
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (4)
Upstream (2)
Downstream (2)
1 – 2 of 2
Pathways (178)
Reactome (5)
KEGG (7)
PathwayCommons (5)
WikiPathways (161)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | L1CAM interactions | ||||
Reactome | Netrin-1 signaling | ||||
Reactome | Recycling pathway of L1 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
L1CAM interactions | ||||
Netrin-1 signaling | ||||
Recycling pathway of L1 | ||||
Viral Interactions (0)
Gene Ontology Terms (93)
Functions (15)
Components (40)
Processes (38)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hair color | 2 | 3 | 0 | 1.1 | 94.2 | ||||
hair colour measurement | 1 | 1 | 1 | 86.6 | |||||
lipoprotein A measurement | 1 | 1 | 1 | 58.4 | |||||
testosterone measurement | 1 | 1 | 1 | 33.1 | |||||
1 | 1 | 1 | 17.8 | ||||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hair color | 0 | 1.1 | 94.2 | ||||
hair colour measurement | 1 | 86.6 | |||||
lipoprotein A measurement | 1 | 58.4 | |||||
testosterone measurement | 1 | 33.1 | |||||
1 | 17.8 | ||||||
Find similar targets by:
IDG Resources
Orthologs (13)
Publication Statistics
PubMed Score 853.48
PubMed score by year
PubTator Score 446.09
PubTator score by year
Related Publications
Text Mined References (437)
GeneRif Annotations (333)
Items per page:
0 of 0
PMID | Year | Title |
|---|