You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
EZH2
Histone-lysine N-methyltransferase EZH2

Protein Summary
Description
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320356
  • ENSP00000320147
  • ENSG00000106462
  • ENST00000350995
  • ENSP00000223193
  • ENST00000460911
  • ENSP00000419711
  • ENST00000476773
  • ENSP00000419050
  • ENST00000478654
  • ENSP00000417062
  • ENST00000483967
  • ENSP00000419856

Symbol
  • KMT6
  • WVS
  • ENX1
  • KMT6
  • WVS2
  • ENX-1
  • EZH2b
  • KMT6A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.91
transcription factor binding site profile
0.87
histone modification site profile
0.83
transcription factor
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2495.16   (req: < 5)
Gene RIFs: 804   (req: <= 3)
Antibodies: 763   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2495.16   (req: >= 5)
Gene RIFs: 804   (req: > 3)
Antibodies: 763   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 401
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (401)
S-adenosylhomocysteine
Rendered image for S-adenosylhomocysteine
GSK343
Rendered image for GSK343
UNC1999
Rendered image for UNC1999
CHEMBL4080228
Rendered image for CHEMBL4080228
CHEMBL4569399
Rendered image for CHEMBL4569399
CHEMBL4544978
Rendered image for CHEMBL4544978
CHEMBL4575460
Rendered image for CHEMBL4575460
CHEMBL4593352
Rendered image for CHEMBL4593352
CHEMBL4542135
Rendered image for CHEMBL4542135
CHEMBL4529085
Rendered image for CHEMBL4529085
Protein-Protein Interactions (640)
EPOP
Tdark
Novelty:  0.06087869
p_int:  0.999999994
p_ni:  1e-9
p_wrong:  5e-9
Score:  0.766
Data Source:  BioPlex,STRINGDB
JARID2
Tbio
Family:  TF; Epigenetic
Novelty:  0.00921097
p_int:  0.99999999
p_ni:  5e-9
p_wrong:  4e-9
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
MTF2
Tbio
Family:  Epigenetic
Novelty:  0.01152147
p_int:  0.999999977
p_ni:  2.3e-8
Score:  0.979
Data Source:  BioPlex,Reactome,STRINGDB
PHF1
Tbio
Family:  Epigenetic
Novelty:  0.00430297
p_int:  0.999999944
p_ni:  5.2e-8
p_wrong:  3e-9
Score:  0.977
Data Source:  BioPlex,Reactome,STRINGDB
SUZ12
Tbio
Novelty:  0.00402353
p_int:  0.999999904
p_ni:  6.5e-8
p_wrong:  3.2e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PHF19
Tbio
Family:  Epigenetic
Novelty:  0.02289037
p_int:  0.999999896
p_ni:  1.02e-7
p_wrong:  3e-9
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
EED
Tchem
Novelty:  0.00615758
p_int:  0.999999645
p_ni:  3.55e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
AEBP2
Tbio
Novelty:  0.05974483
p_int:  0.999999498
p_ni:  5e-7
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999996686
p_ni:  0.000003314
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.998880473
p_ni:  0.001045798
p_wrong:  0.000073729
Score:  0.544
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (35)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (57)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Model (ISM)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
7
8
88
body height
3
3
3
82.1
BMI-adjusted waist circumference
3
5
6
79.3
mean corpuscular hemoglobin concentration
1
1
1
65.4
1
1
0
1.1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
8
88
body height
3
82.1
BMI-adjusted waist circumference
6
79.3
mean corpuscular hemoglobin concentration
1
65.4
0
1.1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enhancer of zeste 2 polycomb repressive complex 2 subunit
VGNC:4343
745437
Macaque
enhancer of zeste 2 polycomb repressive complex 2 subunit
709075
Mouse
MGI:107940
14056
Rat
RGD:1595860
312299
Dog
enhancer of zeste 2 polycomb repressive complex 2 subunit
VGNC:40541
475511
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enhancer of zeste 2 polycomb repressive complex 2 subunit
Macaque
enhancer of zeste 2 polycomb repressive complex 2 subunit
Mouse
Rat
Dog
enhancer of zeste 2 polycomb repressive complex 2 subunit
Publication Statistics
PubMed Score 2495.16
PubMed score by year
PubTator Score 1207.36
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title