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Tchem
EZH1
Histone-lysine N-methyltransferase EZH1

Protein Summary
Description
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000428826
  • ENSP00000404658
  • ENSG00000108799
  • ENST00000585893
  • ENSP00000467871
  • ENST00000590078
  • ENSP00000465220
  • ENST00000592743
  • ENSP00000466924

Symbol
  • KIAA0388
  • KMT6B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
transcription factor binding site profile
0.84
cell type or tissue
0.78
microRNA
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.53   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 378   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.53   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (19)
GSK343
Rendered image for GSK343
UNC1999
Rendered image for UNC1999
CHEMBL4080228
Rendered image for CHEMBL4080228
CHEMBL4569399
Rendered image for CHEMBL4569399
CHEMBL4544978
Rendered image for CHEMBL4544978
CHEMBL4575460
Rendered image for CHEMBL4575460
CHEMBL4593352
Rendered image for CHEMBL4593352
CHEMBL4542135
Rendered image for CHEMBL4542135
CHEMBL4529085
Rendered image for CHEMBL4529085
CHEMBL4594174
Rendered image for CHEMBL4594174
Protein-Protein Interactions (134)
SUZ12
Tbio
Novelty:  0.00402353
p_int:  0.999999984
p_ni:  1.5e-8
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
PHF19
Tbio
Family:  Epigenetic
Novelty:  0.02289037
p_int:  0.999998633
p_ni:  0.000001349
p_wrong:  1.8e-8
Score:  0.941
Data Source:  BioPlex,STRINGDB
EED
Tchem
Novelty:  0.00615758
Score:  0.997
Data Source:  STRINGDB
AEBP2
Tbio
Novelty:  0.05974483
Score:  0.993
Data Source:  STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
Score:  0.991
Data Source:  STRINGDB
RBBP4
Tbio
Novelty:  0.01062843
Score:  0.99
Data Source:  STRINGDB
RING1
Tbio
Family:  Enzyme
Novelty:  0.00729948
Score:  0.974
Data Source:  STRINGDB
RNF2
Tbio
Family:  Enzyme
Novelty:  0.00859204
Score:  0.973
Data Source:  STRINGDB
CBX4
Tchem
Family:  Epigenetic
Novelty:  0.02681197
Score:  0.97
Data Source:  STRINGDB
CBX6
Tchem
Family:  Epigenetic
Novelty:  0.08868575
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
5
5
80.9
BMI-adjusted waist-hip ratio
2
5
5
78.5
waist circumference
1
2
2
43.8
triglyceride measurement
1
1
1
38.8
2
1
1
1.1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
5
80.9
BMI-adjusted waist-hip ratio
5
78.5
waist circumference
2
43.8
triglyceride measurement
1
38.8
1
1.1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enhancer of zeste 1 polycomb repressive complex 2 subunit
VGNC:9279
454697
Macaque
enhancer of zeste 1 polycomb repressive complex 2 subunit
711173
Mouse
MGI:1097695
14055
Rat
RGD:1305028
303547
Dog
enhancer of zeste 1 polycomb repressive complex 2 subunit
VGNC:40540
480516
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enhancer of zeste 1 polycomb repressive complex 2 subunit
Macaque
enhancer of zeste 1 polycomb repressive complex 2 subunit
Mouse
Rat
Dog
enhancer of zeste 1 polycomb repressive complex 2 subunit
Publication Statistics
PubMed Score 38.53
PubMed score by year
PubTator Score 39.77
PubTator score by year
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Related Publications
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PMID
Year
Title