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Tbio
EYS
Protein eyes shut homolog

Protein Summary
Description
Required to maintain the integrity of photoreceptor cells. The product of this gene contains multiple epidermal growth factor (EGF)-like and LamG domains. The protein is expressed in the photoreceptor layer of the retina, and the gene is mutated in autosomal recessive retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342421
  • ENSP00000341818
  • ENSG00000188107
  • ENST00000370621
  • ENSP00000359655
  • ENST00000393380
  • ENSP00000377042
  • ENST00000503581
  • ENSP00000424243

Symbol
  • C6orf178
  • C6orf179
  • C6orf180
  • EGFL10
  • EGFL11
  • SPAM
  • RP25
  • SPAM
  • EGFL10
  • EGFL11
  • C6orf178
  • C6orf179
  • C6orf180
  • bA74E24.1
  • dJ22I17.2
  • bA166P24.2
  • bA307F22.3
  • dJ1018A4.2
  • dJ303F19.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.86
cell line
0.66
disease
0.63
phenotype
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.8   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.8   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0