Protein Summary
Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
- ENST00000343631
- ENSP00000342656
- ENSG00000151348
- ENST00000358681
- ENSP00000351509
- ENST00000395673
- ENSP00000379032
- ENST00000533608
- ENSP00000431173
- SOTV
- SSMS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.99 | ||
disease perturbation | 0.83 | ||
cellular component | 0.8 | ||
virus perturbation | 0.76 | ||
transcription factor binding site profile | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 201.77 (req: < 5)
Gene RIFs: 63 (req: <= 3)
Antibodies: 218 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 201.77 (req: >= 5)
Gene RIFs: 63 (req: > 3)
Antibodies: 218 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (88)
INVS
Novelty: 0.00834489
p_int: 0.999988048
p_ni: 3.18e-7
p_wrong: 0.000011635
Score: 0.359
Data Source: BioPlex,STRINGDB
TTC19
Novelty: 0.08251578
p_int: 0.999906537
p_ni: 0.000093443
p_wrong: 2e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
RBFA
Novelty: 0.1061138
p_int: 0.997134008
p_ni: 0.000025766
p_wrong: 0.002840226
Score: 0.163
Data Source: BioPlex,STRINGDB
EXT1
Family: Enzyme
Novelty: 0.00355951
p_int: 0.995706036
p_ni: 0.004293964
Score: 0.955
Data Source: BioPlex,Reactome,STRINGDB
AFAP1
Novelty: 0.00859495
p_int: 0.991335525
p_ni: 2.7e-8
p_wrong: 0.008664448
Score: 0.359
Data Source: BioPlex,STRINGDB
ATE1
Family: Enzyme
Novelty: 0.01672896
p_int: 0.988848392
p_ni: 0.011151608
Data Source: BioPlex
P39880
Novelty: 0.00415896
p_int: 0.984977607
p_ni: 0.015022393
Score: 0.221
Data Source: BioPlex,STRINGDB
USP30
Family: Enzyme
Novelty: 0.03427211
p_int: 0.979750387
p_ni: 0.020249612
p_wrong: 1e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
NOP9
Novelty: 2.89535198
p_int: 0.898708476
p_ni: 0.101291403
p_wrong: 1.21e-7
Score: 0.173
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (24)
Reactome (10)
KEGG (2)
UniProt (1)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | ||||
Reactome | Defective EXT2 causes exostoses 2 | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with glycosaminoglycan metabolism | ||||
Reactome | Diseases of glycosylation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Defective EXT1 causes exostoses 1, TRPS2 and CHDS | ||||
Defective EXT2 causes exostoses 2 | ||||
Disease | ||||
Diseases associated with glycosaminoglycan metabolism | ||||
Diseases of glycosylation | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (7)
Components (8)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
puberty onset measurement | 4 | 1 | 4 | 74.8 | |||||
balding measurement | 1 | 1 | 1 | 61.4 | |||||
synophrys measurement | 1 | 1 | 1 | 56.2 | |||||
1 | 1 | 0 | 1.1 | 30.2 | |||||
1 | 1 | 0 | 1 | 0 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
puberty onset measurement | 4 | 74.8 | |||||
balding measurement | 1 | 61.4 | |||||
synophrys measurement | 1 | 56.2 | |||||
0 | 1.1 | 30.2 | |||||
0 | 1 | 0 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | exostosin glycosyltransferase 2 | VGNC:11348 | 451140 | |||||
Macaque | exostosin glycosyltransferase 2 | 715975 | ||||||
Mouse | MGI:108050 | 14043 | ||||||
Rat | RGD:1307707 | 311215 | ||||||
Dog | exostosin glycosyltransferase 2 | VGNC:40532 | 475989 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | exostosin glycosyltransferase 2 | |||||
Macaque | exostosin glycosyltransferase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | exostosin glycosyltransferase 2 | |||||
Publication Statistics
PubMed Score 201.77
PubMed score by year
PubTator Score 136.80
PubTator score by year
Related Publications
Text Mined References (104)
GeneRif Annotations (63)
Items per page:
0 of 0
PMID | Year | Title |
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