Protein Summary
Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses. [provided by RefSeq, Jul 2008]
- ENST00000378204
- ENSP00000367446
- ENSG00000182197
- EXT
- LGS
- TTV
- LGCR
- TRPS2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.95 | ||
kinase perturbation | 0.93 | ||
transcription factor binding site profile | 0.91 | ||
transcription factor perturbation | 0.88 | ||
trait | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 313.28 (req: < 5)
Gene RIFs: 69 (req: <= 3)
Antibodies: 224 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 313.28 (req: >= 5)
Gene RIFs: 69 (req: > 3)
Antibodies: 224 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (96)
ZP2
Novelty: 0.00310166
p_int: 0.999913297
p_ni: 0.000085941
p_wrong: 7.62e-7
Data Source: BioPlex
EXT2
Family: Enzyme
Novelty: 0.00480574
p_int: 0.995706036
p_ni: 0.004293964
Score: 0.955
Data Source: BioPlex,Reactome,STRINGDB
SCGB2A2
Novelty: 0.01594053
p_int: 0.993534049
p_ni: 0.006465951
Score: 0.164
Data Source: BioPlex,STRINGDB
ERGIC3
Novelty: 0.11095443
p_int: 0.990752855
p_ni: 0.009247145
Score: 0.22
Data Source: BioPlex,STRINGDB
PTCH1
Novelty: 0.00077635
p_int: 0.987348231
p_ni: 0.012651769
Score: 0.355
Data Source: BioPlex,STRINGDB
B4GAT1
Family: Enzyme
Novelty: 0.14959923
p_int: 0.984093387
p_ni: 0.015906613
Score: 0.385
Data Source: BioPlex,STRINGDB
PEX19
Novelty: 0.00605342
p_int: 0.978684488
p_ni: 0.021315509
p_wrong: 3e-9
Data Source: BioPlex
GRAMD1B
Novelty: 0.2994102
p_int: 0.97053692
p_ni: 0.029462311
p_wrong: 7.69e-7
Data Source: BioPlex
LRRC55
Family: IC
Novelty: 0.25121277
p_int: 0.968087754
p_ni: 0.031908532
p_wrong: 0.000003714
Data Source: BioPlex
Nearest Tclin Targets
Pathways (15)
Reactome (10)
KEGG (2)
UniProt (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | ||||
Reactome | Defective EXT2 causes exostoses 2 | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with glycosaminoglycan metabolism | ||||
Reactome | Diseases of glycosylation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Defective EXT1 causes exostoses 1, TRPS2 and CHDS | ||||
Defective EXT2 causes exostoses 2 | ||||
Disease | ||||
Diseases associated with glycosaminoglycan metabolism | ||||
Diseases of glycosylation | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (9)
Components (6)
Processes (14)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
basophil count | 3 | 2 | 3 | 83.8 | |||||
mathematical ability | 3 | 3 | 3 | 68 | |||||
self reported educational attainment | 1 | 1 | 1 | 61 | |||||
body mass index | 2 | 1 | 2 | 57.3 | |||||
cognitive function measurement | 1 | 1 | 1 | 46.9 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
basophil count | 3 | 83.8 | |||||
mathematical ability | 3 | 68 | |||||
self reported educational attainment | 1 | 61 | |||||
body mass index | 2 | 57.3 | |||||
cognitive function measurement | 1 | 46.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | exostosin glycosyltransferase 1 | VGNC:12003 | 464349 | |||||
Macaque | exostosin glycosyltransferase 1 | 701488 | ||||||
Mouse | MGI:894663 | 14042 | ||||||
Rat | RGD:1587375 | 299907 | ||||||
Dog | exostosin glycosyltransferase 1 | VGNC:40531 | 482024 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | exostosin glycosyltransferase 1 | |||||
Macaque | exostosin glycosyltransferase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | exostosin glycosyltransferase 1 | |||||
Publication Statistics
PubMed Score 313.28
PubMed score by year
PubTator Score 214.13
PubTator score by year
Related Publications
Text Mined References (96)
GeneRif Annotations (69)
Items per page:
0 of 0
PMID | Year | Title |
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