Protein Summary
May act as Rab effector protein and play a role in vesicle trafficking. The protein encoded by this gene is a member of the synaptotagmin-like protein (Slp) family lacking a C2 domain. It contains an N-terminal synaptotagmin-like homology domain (SHD), and is a ras-related protein Rab-27B effector protein. This protein is thought to be involved in exosome secretion and intracellular vesicle trafficking. Reduced expression of this gene results in keratin filament defects. Mutations in this gene have been associated with some cases of epidermolysis bullosa, an inherited skin fragility disorder. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
- ENST00000265843
- ENSP00000265843
- ENSG00000110723
- ENST00000525344
- ENSP00000432546
- KIAA0624
- SLAC2B
- SLAC2B
- SLAC2-B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.78 | ||
interacting protein | 0.71 | ||
gene perturbation | 0.68 | ||
cell type or tissue | 0.66 | ||
microRNA | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.78 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 45 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.78 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 45 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (45)
NCAPH2
Novelty: 0.12134933
p_int: 0.999971361
p_ni: 0.000027553
p_wrong: 0.000001086
Data Source: BioPlex
PRELID2
Novelty: 0.38276284
p_int: 0.999942622
p_ni: 0.000046737
p_wrong: 0.000010641
Data Source: BioPlex
HAVCR2
Novelty: 0.00155885
p_int: 0.999860248
p_ni: 0.000139307
p_wrong: 4.45e-7
Data Source: BioPlex
RAB27A
Family: Enzyme
Novelty: 0.00369416
p_int: 0.999465439
p_ni: 0.00030303
p_wrong: 0.000231531
Score: 0.904
Data Source: BioPlex,STRINGDB
SKAP1
Family: Enzyme
Novelty: 0.03753848
p_int: 0.947987743
p_ni: 0.000236033
p_wrong: 0.051776224
Score: 0.186
Data Source: BioPlex,STRINGDB
HSPB8
Novelty: 0.00298618
p_int: 0.842106271
p_ni: 0.000336864
p_wrong: 0.157556866
Score: 0.187
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Deregulation of Rab and Rab Effector Genes in Bladder Cancer | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Deregulation of Rab and Rab Effector Genes in Bladder Cancer | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (1)
Components (1)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet crit | 1 | 2 | 2 | 90.8 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 83.5 | |||||
red blood cell density measurement | 1 | 1 | 1 | 80.9 | |||||
mean platelet volume | 2 | 2 | 2 | 74.4 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 73.9 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet crit | 2 | 90.8 | |||||
mean corpuscular hemoglobin concentration | 1 | 83.5 | |||||
red blood cell density measurement | 1 | 80.9 | |||||
mean platelet volume | 2 | 74.4 | |||||
mean reticulocyte volume | 1 | 73.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | exophilin 5 | VGNC:1047 | 451533 | |||||
Macaque | exophilin 5 | 708977 | ||||||
Mouse | MGI:2443248 | 320051 | ||||||
Rat | RGD:1560308 | 315663 | ||||||
Dog | exophilin 5 | VGNC:40530 | 489418 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | exophilin 5 | |||||
Macaque | exophilin 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | exophilin 5 | |||||
Publication Statistics
PubMed Score 12.78
PubMed score by year
PubTator Score 8.03
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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