EXOSC8
Exosome complex component RRP43
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.88 | ||
transcription factor binding site profile | 0.77 | ||
co-expressed gene | 0.76 | ||
virus perturbation | 0.76 | ||
histone modification site profile | 0.64 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | ATF4 activates genes in response to endoplasmic reticulum stress | ||||
Reactome | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | ||||
Reactome | Deadenylation-dependent mRNA decay | ||||
Reactome | KSRP (KHSRP) binds and destabilizes mRNA | ||||
Reactome | Major pathway of rRNA processing in the nucleolus and cytosol | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ATF4 activates genes in response to endoplasmic reticulum stress | ||||
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | ||||
Deadenylation-dependent mRNA decay | ||||
KSRP (KHSRP) binds and destabilizes mRNA | ||||
Major pathway of rRNA processing in the nucleolus and cytosol | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 3 | 4 | 81.5 | |||||
bone density | 1 | 1 | 1 | 24.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 4 | 81.5 | |||||
bone density | 1 | 24.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | exosome component 8 | VGNC:5057 | 467263 | |||||
Macaque | exosome component 8 | 695071 | ||||||
Mouse | MGI:1916889 | 69639 | ||||||
Dog | exosome component 8 | VGNC:40528 | 477300 | |||||
Horse | exosome component 8 | VGNC:17737 | 100062567 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | exosome component 8 | |||||
Macaque | exosome component 8 | |||||
Mouse | ||||||
Dog | exosome component 8 | |||||
Horse | exosome component 8 | |||||
PMID | Year | Title |
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