Tbio EXOSC8 Exosome complex component RRP43

Protein Summary

Description

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs. This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q96B26
• O43480
• Q5TBA5

Gene Name

• EXOSC8

Ensembl ID

• ENST00000389704
• ENSP00000374354
• ENSG00000120699

Symbol

• OIP2
• RRP43
• p9
• CIP3
• EAP2
• OIP2
• PCH1C
• RRP43
• Rrp43p
• bA421P11.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.88
transcription factor binding site profile	0.77
co-expressed gene	0.76
virus perturbation	0.76
histone modification site profile	0.64

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Exoribonuclease / Exosome Complex Component Rrp43

Protein / Nucleic Acid Binding / Rna Binding Protein / Exoribonuclease / Exosome Complex Component Rrp43

Protein / Hydrolase / Exosome Complex Component Rrp43

DTO Classes

Protein / Enzyme / Nuclease / Exoribonuclease / Exosome Complex Component Rrp43

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.52   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.52   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0