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Tbio
EXOG
Nuclease EXOG, mitochondrial

Protein Summary
Description
Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity. This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287675
  • ENSP00000287675
  • ENSG00000157036
  • ENST00000422077
  • ENSP00000404305

Symbol
  • ENDOGL1
  • ENDOGL2
  • ENGL
  • ENGL
  • ENGLA
  • ENGLB
  • ENGL-a
  • ENGL-b
  • ENDOGL1
  • ENDOGL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.64
histone modification site profile
0.62
transcription factor perturbation
0.61
cell line
0.58
tissue sample
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.2   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.2   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
HEATR3
Tbio
Novelty:  0.08367436
p_int:  0.999998253
p_ni:  0.000001747
Data Source:  BioPlex
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.999944514
p_ni:  0.000055486
Data Source:  BioPlex
BZW2
Tbio
Novelty:  0.17006204
p_int:  0.99993353
p_ni:  0.00006647
Data Source:  BioPlex
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.999842257
p_ni:  0.000157743
Data Source:  BioPlex
EIF2B2
Tbio
Novelty:  0.03253919
p_int:  0.999827737
p_ni:  0.000172263
Data Source:  BioPlex
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.999418738
p_ni:  0.000580626
p_wrong:  6.36e-7
Data Source:  BioPlex
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.998998776
p_ni:  0.001001224
Data Source:  BioPlex
RANBP6
Tdark
Novelty:  0.75714796
p_int:  0.996846851
p_ni:  0.003153133
p_wrong:  1.6e-8
Score:  0.193
Data Source:  BioPlex,STRINGDB
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.992363581
p_ni:  0.007636113
p_wrong:  3.06e-7
Data Source:  BioPlex
TBC1D22A
Tbio
Novelty:  0.46374046
p_int:  0.986155221
p_ni:  0.013290867
p_wrong:  0.000553913
Score:  0.196
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
PR interval
6
7
0
3.4
97.8
electrocardiography
3
5
66
8.2
97
glomerular filtration rate
4
4
3
6.6
91.6
QT interval
6
6
2
1.6
88
QRS duration
2
2
1
8.2
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
PR interval
0
3.4
97.8
electrocardiography
66
8.2
97
glomerular filtration rate
3
6.6
91.6
QT interval
2
1.6
88
QRS duration
1
8.2
77.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exo/endonuclease G
VGNC:14527
747482
Macaque
exo/endonuclease G
695307
Mouse
MGI:2143333
208194
Rat
RGD:1304628
301062
Dog
exo/endonuclease G
VGNC:40520
485591
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exo/endonuclease G
Macaque
exo/endonuclease G
Mouse
Rat
Dog
exo/endonuclease G
Publication Statistics
PubMed Score 29.20
PubMed score by year
PubTator Score 17.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title