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Tbio
EXOC6B
Exocyst complex component 6B

Protein Summary
Description
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. This gene encodes a protein which is a part of the evolutionarily conserved exocyst, a multimeric protein complex necessary for exocytosis, which in turn, is crucial for cell growth, polarity and migration. Disruption of this gene may be associated with phenotypes exhibiting multiple symptoms including intellectual disability and developmental delay (DD). [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272427
  • ENSP00000272427
  • ENSG00000144036

Symbol
  • KIAA0919
  • SEC15B
  • SEC15L2
  • SEC15B
  • SEC15L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.68
histone modification site profile
0.63
transcription factor binding site profile
0.63
microRNA
0.61
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.09   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.09   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
IL1R2
Tbio
Novelty:  0.00820359
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.551
Data Source:  BioPlex,STRINGDB
EXOC8
Tbio
Novelty:  0.03090842
p_int:  0.999999922
p_ni:  7.7e-8
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
EXOC3
Tbio
Novelty:  0.01051955
p_int:  0.999998908
p_ni:  0.000001092
Score:  0.986
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.999908898
p_ni:  0.000091102
Score:  0.943
Data Source:  BioPlex,STRINGDB
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.999705538
p_ni:  0.000294462
Score:  0.401
Data Source:  BioPlex,STRINGDB
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.999139301
p_ni:  0.000860699
Data Source:  BioPlex
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.993609102
p_ni:  0.006390897
Score:  0.245
Data Source:  BioPlex,STRINGDB
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.987304873
p_ni:  0.012275943
p_wrong:  0.000419184
Data Source:  BioPlex
CA14
Tclin
Family:  Enzyme
Novelty:  0.00864764
p_int:  0.975092244
p_ni:  0.024907724
p_wrong:  3.2e-8
Data Source:  BioPlex
EXOC7
Tbio
Novelty:  0.00852508
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
3
3
92.8
brain measurement
1
1
0
8.2
56.8
schizophrenia
1
1
0
1.1
49.9
diastolic blood pressure
1
1
1
41.3
C-reactive protein measurement
2
2
2
41.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
92.8
brain measurement
0
8.2
56.8
schizophrenia
0
1.1
49.9
diastolic blood pressure
1
41.3
C-reactive protein measurement
2
41.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exocyst complex component 6B
VGNC:248
459318
Mouse
MGI:1923164
75914
Rat
RGD:1560638
500233
Dog
exocyst complex component 6B
VGNC:40517
483119
Horse
exocyst complex component 6B
VGNC:17726
100059535
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exocyst complex component 6B
Mouse
Rat
Dog
exocyst complex component 6B
Horse
exocyst complex component 6B
Publication Statistics
PubMed Score 10.09
PubMed score by year
PubTator Score 6.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title