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Tbio
EXOC3L2
Exocyst complex component 3-like protein 2

Protein Summary
Description
The protein encoded by this gene is upregulated by vascular endothelial growth factor A and interacts with exocyst complex component 4. The encoded protein may be part of an exocyst complex that plays a role in cell membrane dynamics. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252482
  • ENSP00000252482
  • ENSG00000283632

Symbol
  • XTP7
  • XTP7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.72
tissue sample
0.64
tissue
0.59
cell line
0.55
kinase perturbation
0.42


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.89   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.89   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
SIAH1
Tbio
Family:  Enzyme
Novelty:  0.00831224
p_int:  0.999993038
p_ni:  0.000006962
Score:  0.416
Data Source:  BioPlex,STRINGDB
MIPEP
Tbio
Family:  Enzyme
Novelty:  0.01507033
p_int:  0.99671742
p_ni:  0.00328258
Score:  0.246
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.808182977
p_ni:  0.191817023
Data Source:  BioPlex
EXOC4
Tbio
Novelty:  0.01636648
Score:  0.899
Data Source:  STRINGDB
EXOC5
Tbio
Novelty:  0.02200205
Score:  0.888
Data Source:  STRINGDB
EXOC7
Tbio
Novelty:  0.00852508
Score:  0.882
Data Source:  STRINGDB
EXOC8
Tbio
Novelty:  0.03090842
Score:  0.84
Data Source:  STRINGDB
EXOC2
Tbio
Novelty:  0.01434464
Score:  0.822
Data Source:  STRINGDB
PICALM
Tbio
Novelty:  0.00800832
Score:  0.728
Data Source:  STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
Score:  0.716
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
4
4
7
98.4
mean platelet volume
4
3
5
98
platelet count
3
5
4
2.6
97.6
leukocyte count
2
3
3
97.4
2
9
0
7
97.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
7
98.4
mean platelet volume
5
98
platelet count
4
2.6
97.6
leukocyte count
3
97.4
0
7
97.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1921713
74463
Dog
exocyst complex component 3 like 2
484450
Cow
exocyst complex component 3 like 2
539328
Zebrafish
ZDB-GENE-100728-5
565839
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
exocyst complex component 3 like 2
Cow
exocyst complex component 3 like 2
Zebrafish
Publication Statistics
PubMed Score 5.89
PubMed score by year
PubTator Score 7.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title