Protein Summary
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000348581
- ENSP00000311873
- ENSG00000174371
- ENST00000366548
- ENSP00000355506
- ENST00000518483
- ENSP00000430251
- EXOI
- HEX1
- HEX1
- hExoI
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
histone modification site profile | 0.92 | ||
protein domain | 0.85 | ||
transcription factor binding site profile | 0.82 | ||
disease | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 757.74 (req: < 5)
Gene RIFs: 68 (req: <= 3)
Antibodies: 352 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 757.74 (req: >= 5)
Gene RIFs: 68 (req: > 3)
Antibodies: 352 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (418)
WDR83
Novelty: 0.11602568
p_int: 0.997060394
p_ni: 6e-9
p_wrong: 0.002939601
Score: 0.391
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (37)
Reactome (25)
KEGG (1)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Reactome | DNA Double-Strand Break Repair | ||||
Reactome | DNA Repair | ||||
Reactome | G2/M Checkpoints | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
DNA Double-Strand Break Repair | ||||
DNA Repair | ||||
G2/M Checkpoints | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (12)
Components (4)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
age at menopause | 2 | 2 | 2 | 71.4 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 61 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 52.7 | |||||
eosinophil count | 1 | 1 | 1 | 44.2 | |||||
keratinocyte carcinoma | 1 | 1 | 0 | 1.2 | 33.1 | ||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
age at menopause | 2 | 71.4 | |||||
mean corpuscular hemoglobin concentration | 1 | 61 | |||||
eosinophil percentage of leukocytes | 1 | 52.7 | |||||
eosinophil count | 1 | 44.2 | |||||
keratinocyte carcinoma | 0 | 1.2 | 33.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | exonuclease 1 | VGNC:1236 | 457856 | |||||
Macaque | exonuclease 1 | 706902 | ||||||
Mouse | MGI:1349427 | 26909 | ||||||
Rat | RGD:1309465 | 305000 | ||||||
Dog | exonuclease 1 | VGNC:40511 | 100855525 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | exonuclease 1 | |||||
Macaque | exonuclease 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | exonuclease 1 | |||||
Publication Statistics
PubMed Score 757.74
PubMed score by year
PubTator Score 262.09
PubTator score by year
Related Publications
Text Mined References (105)
GeneRif Annotations (68)
Items per page:
0 of 0
PMID | Year | Title |
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