You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EXO1
Exonuclease 1

Protein Summary
Description
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348581
  • ENSP00000311873
  • ENSG00000174371
  • ENST00000366548
  • ENSP00000355506
  • ENST00000518483
  • ENSP00000430251

Symbol
  • EXOI
  • HEX1
  • HEX1
  • hExoI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
histone modification site profile
0.92
protein domain
0.85
transcription factor binding site profile
0.82
disease
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 757.74   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 352   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 757.74   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (418)
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.997060394
p_ni:  6e-9
p_wrong:  0.002939601
Score:  0.391
Data Source:  BioPlex,STRINGDB
MSH2
Tbio
Novelty:  0.00054283
Score:  0.999
Data Source:  Reactome,STRINGDB
DNA2
Tbio
Family:  Enzyme
Novelty:  0.00195682
Score:  0.999
Data Source:  STRINGDB
MLH1
Tbio
Novelty:  0.00034212
Score:  0.998
Data Source:  Reactome,STRINGDB
BLM
Tchem
Novelty:  0.00662454
Score:  0.998
Data Source:  STRINGDB
RAD51
Tchem
Novelty:  0.00011516
Score:  0.997
Data Source:  STRINGDB
PMS2
Tbio
Family:  Enzyme
Novelty:  0.00139084
Score:  0.997
Data Source:  Reactome,STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.997
Data Source:  Reactome,STRINGDB
CHEK1
Tchem
Family:  Kinase
Novelty:  0.00066843
Score:  0.997
Data Source:  STRINGDB
RAD52
Tchem
Novelty:  0.00125282
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (37)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
G2/M Checkpoints
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double-Strand Break Repair
DNA Repair
G2/M Checkpoints
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
2
2
71.4
mean corpuscular hemoglobin concentration
1
1
1
61
eosinophil percentage of leukocytes
1
1
1
52.7
eosinophil count
1
1
1
44.2
keratinocyte carcinoma
1
1
0
1.2
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
71.4
mean corpuscular hemoglobin concentration
1
61
eosinophil percentage of leukocytes
1
52.7
eosinophil count
1
44.2
keratinocyte carcinoma
0
1.2
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exonuclease 1
VGNC:1236
457856
Macaque
exonuclease 1
706902
Mouse
MGI:1349427
26909
Rat
RGD:1309465
305000
Dog
exonuclease 1
VGNC:40511
100855525
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exonuclease 1
Macaque
exonuclease 1
Mouse
Rat
Dog
exonuclease 1
Publication Statistics
PubMed Score 757.74
PubMed score by year
PubTator Score 262.09
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title