Tbio EWSR1 RNA-binding protein EWS

Protein Summary

Description

Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]

Uniprot Accession IDs

• Q01844
• B0QYK1
• Q5THL0
• Q92635
• Q96FE8
• Q96MN4
• Q96MX4
• Q9BWA2

Gene Name

• EWSR1

Ensembl ID

• ENST00000332035
• ENSP00000331699
• ENSG00000182944
• ENST00000333395
• ENSP00000327456
• ENST00000397938
• ENSP00000381031
• ENST00000406548
• ENSP00000385726
• ENST00000414183
• ENSP00000400142

Symbol

• EWS
• EWS
• EWS-FLI1
• bK984G1.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
hub protein	0.99
kinase	0.95
transcription factor binding site profile	0.79
tissue	0.76

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Rna-binding Protein Ews

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Rna-binding Protein Ews

Protein / Nucleic Acid Binding / Dna Binding Protein / Rna-binding Protein Ews

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Rna-binding Protein Ews

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1994.3   (req: < 5)

Gene RIFs: 245   (req: <= 3)

Antibodies: 504   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1994.3   (req: >= 5)

Gene RIFs: 245   (req: > 3)

Antibodies: 504   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0