You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EVPL
Envoplakin

Protein Summary
Description
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301607
  • ENSP00000301607
  • ENSG00000167880

Symbol
  • EVPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.71
gene perturbation
0.66
small molecule perturbation
0.63
cell line
0.55
tissue sample
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.58   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.58   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (147)
FCF1
Tdark
Novelty:  0.04202976
p_int:  0.999918964
p_ni:  0.000080997
p_wrong:  3.9e-8
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.999889213
p_ni:  0.000110647
p_wrong:  1.4e-7
Score:  0.163
Data Source:  BioPlex,STRINGDB
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.999662266
p_ni:  0.000337719
p_wrong:  1.6e-8
Data Source:  BioPlex
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.999570869
p_ni:  0.000429127
p_wrong:  4e-9
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.99956262
p_ni:  0.00043738
Data Source:  BioPlex
MUM1
Tbio
Family:  Epigenetic
Novelty:  0.11597088
p_int:  0.9990895
p_ni:  0.0009105
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.998418652
p_ni:  0.001581348
Data Source:  BioPlex
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
p_int:  0.997651231
p_ni:  0.002348766
p_wrong:  3e-9
Data Source:  BioPlex
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.996367263
p_ni:  0.003632737
Score:  0.159
Data Source:  BioPlex,STRINGDB
CCNYL1
Tdark
Novelty:  0.45350824
p_int:  0.993280041
p_ni:  0.006719959
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
2
2
2
73.4
mean platelet volume
1
1
1
60.5
comparative body size at age 10, self-reported
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
2
73.4
mean platelet volume
1
60.5
comparative body size at age 10, self-reported
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
envoplakin
VGNC:9422
454896
Macaque
envoplakin
705079
Mouse
MGI:107507
14027
Rat
RGD:1306141
303687
Dog
envoplakin
VGNC:51954
483324
Species
Name
OMA
EggNOG
Inparanoid
Chimp
envoplakin
Macaque
envoplakin
Mouse
Rat
Dog
envoplakin
Publication Statistics
PubMed Score 334.58
PubMed score by year
PubTator Score 45.75
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title