You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EVI5L
EVI5-like protein

Protein Summary
Description
Functions as a GTPase-activating protein (GAP) with a broad specificity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270530
  • ENSP00000270530
  • ENSG00000142459
  • ENST00000538904
  • ENSP00000445905
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.81
histone modification site profile
0.68
cell type or tissue
0.67
tissue sample
0.64
transcription factor binding site profile
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.91   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.91   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
FIS1
Tbio
Novelty:  0.0033607
p_int:  0.999840221
p_ni:  0.000158733
p_wrong:  0.000001046
Data Source:  BioPlex
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.999443557
p_ni:  0.000556422
p_wrong:  2.1e-8
Data Source:  BioPlex
RAB43
Tbio
Family:  Enzyme
Novelty:  0.07527576
p_int:  0.99926925
p_ni:  0.000729157
p_wrong:  0.000001593
Score:  0.328
Data Source:  BioPlex,STRINGDB
SIGLECL1
Tdark
p_int:  0.997690436
p_ni:  0.002267725
p_wrong:  0.00004184
Data Source:  BioPlex
FZD10
Tbio
Family:  GPCR
Novelty:  0.02786933
p_int:  0.997249611
p_ni:  0.00267351
p_wrong:  0.00007688
Data Source:  BioPlex
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.997028748
p_ni:  0.001127386
p_wrong:  0.001843865
Data Source:  BioPlex
PTGER3
Tclin
Family:  GPCR
Novelty:  0.0012681
p_int:  0.996778055
p_ni:  0.00311522
p_wrong:  0.000106726
Data Source:  BioPlex
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.995838675
p_ni:  0.00411629
p_wrong:  0.000045034
Data Source:  BioPlex
TSPYL1
Tbio
Novelty:  0.06381144
p_int:  0.994827188
p_ni:  0.004620138
p_wrong:  0.000552675
Data Source:  BioPlex
P2RX2
Tchem
Family:  IC
Novelty:  0.00241146
p_int:  0.982676106
p_ni:  0.01616645
p_wrong:  0.001157444
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
4
93
leukocyte count
2
3
3
89.1
4
3
2
1
86.8
myeloid white cell count
2
2
2
86.2
aspartate aminotransferase measurement
1
1
0
9.5
73.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
93
leukocyte count
3
89.1
2
1
86.8
myeloid white cell count
2
86.2
aspartate aminotransferase measurement
0
9.5
73.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ecotropic viral integration site 5 like
VGNC:7688
100612415
Macaque
ecotropic viral integration site 5 like
706628
Mouse
MGI:2442167
213027
Dog
ecotropic viral integration site 5 like
485001
Cow
ecotropic viral integration site 5 like
VGNC:54622
536625
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ecotropic viral integration site 5 like
Macaque
ecotropic viral integration site 5 like
Mouse
Dog
ecotropic viral integration site 5 like
Cow
ecotropic viral integration site 5 like
Publication Statistics
PubMed Score 1.91
PubMed score by year
PubTator Score 0.70
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title