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Tbio
EVI2B
Protein EVI2B

Protein Summary
Description
Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330927
  • ENSP00000333779
  • ENSG00000185862
  • ENST00000577894
  • ENSP00000462682

Symbol
  • EVDB
  • EVDB
  • CD361
  • D17S376
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.8
kinase perturbation
0.71
transcription factor perturbation
0.61
gene perturbation
0.58
tissue
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.85   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.85   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
EVI2A
Tbio
Novelty:  0.02320553
Score:  0.978
Data Source:  STRINGDB
CD53
Tbio
Novelty:  0.01722633
Score:  0.83
Data Source:  STRINGDB
OMG
Tbio
Novelty:  0.00993333
Score:  0.805
Data Source:  STRINGDB
LAPTM5
Tbio
Novelty:  0.06809459
Score:  0.777
Data Source:  STRINGDB
PTPRC
Tchem
Family:  Enzyme
Novelty:  0.00012027
Score:  0.773
Data Source:  STRINGDB
RNF135
Tbio
Family:  Enzyme
Novelty:  0.05600338
Score:  0.712
Data Source:  STRINGDB
LCP2
Tbio
Novelty:  0.00512968
Score:  0.689
Data Source:  STRINGDB
HCLS1
Tbio
Novelty:  0.08304056
Score:  0.679
Data Source:  STRINGDB
SSH2
Tbio
Family:  Enzyme
Novelty:  0.05112042
Score:  0.65
Data Source:  STRINGDB
NF1
Tbio
Novelty:  0.00019092
Score:  0.644
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
90.3
risk-taking behaviour
2
2
2
83.4
3
3
2
1.1
80.7
platelet count
1
1
1
71.9
total cholesterol measurement
3
2
3
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
90.3
risk-taking behaviour
2
83.4
2
1.1
80.7
platelet count
1
71.9
total cholesterol measurement
3
71.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ecotropic viral integration site 2B
VGNC:9278
748458
Macaque
ecotropic viral integration site 2B
712972
Mouse
MGI:5439444
101488212
Rat
RGD:6495961
100910940
Dog
ecotropic viral integration site 2B
VGNC:53237
610438
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ecotropic viral integration site 2B
Macaque
ecotropic viral integration site 2B
Mouse
Rat
Dog
ecotropic viral integration site 2B
Publication Statistics
PubMed Score 7.85
PubMed score by year
PubTator Score 4.66
PubTator score by year
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Related Publications
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PMID
Year
Title