Tbio EVC Ellis-van Creveld syndrome protein

Protein Summary

Description

Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development. This gene encodes a protein containing a leucine zipper and a transmembrane domain. This gene has been implicated in both Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P57679

Gene Name

• EVC

Ensembl ID

• ENST00000264956
• ENSP00000264956
• ENSG00000072840

Symbol

• EVC1
• EVCL
• DWF-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.79
transcription factor perturbation	0.74
gene perturbation	0.58
cell type or tissue	0.56
PubMedID	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.89   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.89   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0