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Tbio
EVA1A
Protein eva-1 homolog A

Protein Summary
Description
Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233712
  • ENSP00000233712
  • ENSG00000115363
  • ENST00000393913
  • ENSP00000377490
  • ENST00000410071
  • ENSP00000386930
  • ENST00000410113
  • ENSP00000386435

Symbol
  • FAM176A
  • TMEM166
  • FAM176A
  • TMEM166
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
trait
0.86
PubMedID
0.7
tissue sample
0.64
phenotype
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.66   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.66   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (134)
APOB
Tchem
Novelty:  0.00008247
Score:  0.943
Data Source:  STRINGDB
CYR61
Tbio
Novelty:  0.0028995
Score:  0.918
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.918
Data Source:  STRINGDB
IGFBP3
Tchem
Novelty:  0.0003776
Score:  0.914
Data Source:  STRINGDB
APOE
Tbio
Novelty:  0.00005049
Score:  0.914
Data Source:  STRINGDB
TGOLN2
Tbio
Novelty:  0.005107
Score:  0.913
Data Source:  STRINGDB
LAMB1
Tbio
Novelty:  0.0104285
Score:  0.912
Data Source:  STRINGDB
FSTL1
Tbio
Novelty:  0.00557848
Score:  0.912
Data Source:  STRINGDB
TNC
Tbio
Novelty:  0.0052441
Score:  0.911
Data Source:  STRINGDB
LAMC1
Tbio
Novelty:  0.01230796
Score:  0.91
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
61
serum gamma-glutamyl transferase measurement
1
1
1
45.9
educational attainment
1
2
2
21.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
61
serum gamma-glutamyl transferase measurement
1
45.9
educational attainment
2
21.1
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eva-1 homolog A, regulator of programmed cell death
VGNC:10547
470413
Mouse
MGI:2385247
232146
Rat
RGD:1559797
500221
Dog
eva-1 homolog A, regulator of programmed cell death
483095
Horse
eva-1 homolog A, regulator of programmed cell death [Source:HGNC Symbol;Acc:HGNC:25816]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eva-1 homolog A, regulator of programmed cell death
Mouse
Rat
Dog
eva-1 homolog A, regulator of programmed cell death
Horse
eva-1 homolog A, regulator of programmed cell death [Source:HGNC Symbol;Acc:HGNC:25816]
Publication Statistics
PubMed Score 69.66
PubMed score by year
PubTator Score 9.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title