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Tbio
ETV7
Transcription factor ETV7

Protein Summary
Description
Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor activity. The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339796
  • ENSP00000342260
  • ENSG00000010030
  • ENST00000340181
  • ENSP00000341843
  • ENST00000373737
  • ENSP00000362842
  • ENST00000373738
  • ENSP00000362843
  • ENST00000538992
  • ENSP00000440592
  • ENST00000615781
  • ENSP00000481885
  • ENST00000620358
  • ENSP00000484485
  • ENST00000627426
  • ENSP00000486712

Symbol
  • TEL2
  • TELB
  • TREF
  • TEL2
  • TELB
  • TEL-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
tissue sample
0.64
molecular function
0.63
histone modification site profile
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.74   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.74   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0