Tbio ETV1 ETS translocation variant 1

Protein Summary

Description

Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• P50549
• A4D118
• B2R768
• B7Z2I4
• B7Z618
• B7Z9P2
• C9JT37
• E9PHB1
• F5GXR2
• O75849
• Q4KMQ6
• Q59GA7
• Q6AI30
• Q9UQ71
• Q9Y636

Gene Name

• ETV1

Ensembl ID

• ENST00000242066
• ENSP00000242066
• ENSG00000006468
• ENST00000399357
• ENSP00000382293
• ENST00000403527
• ENSP00000384138
• ENST00000403685
• ENSP00000385686
• ENST00000405192
• ENSP00000385381
• ENST00000405218
• ENSP00000385551
• ENST00000420159
• ENSP00000411626
• ENST00000430479
• ENSP00000405327

Symbol

• ER81
• ER81

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
PubMedID	0.95
gene perturbation	0.83
transcription factor binding site profile	0.82
transcription factor	0.8

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Ets Translocation Variant 1

Protein / Signaling Molecule / Ets Translocation Variant 1

Protein / Nucleic Acid Binding / Ets Translocation Variant 1

Protein / ... / Winged Helix/forkhead Transcription Factor / Ets Translocation Variant 1

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Ets Translocation Variant 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.29   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 276   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.29   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0