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Tbio
ETNK1
Ethanolamine kinase 1

Protein Summary
Description
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266517
  • ENSP00000266517
  • ENSG00000139163
  • ENST00000335148
  • ENSP00000334041

Symbol
  • EKI1
  • EKI
  • EKI1
  • EKI 1
  • Nbla10396
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
molecular function
0.9
microRNA
0.84
transcription factor binding site profile
0.77
transcription factor
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.76   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.76   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
PNLIP
Tclin
Family:  Enzyme
Novelty:  0.00043254
p_int:  0.999991136
p_ni:  0.000008863
p_wrong:  1e-9
Score:  0.243
Data Source:  BioPlex,STRINGDB
NASP
Tbio
Novelty:  0.00902599
p_int:  0.999683058
p_ni:  0.00031518
p_wrong:  0.000001761
Score:  0.188
Data Source:  BioPlex,STRINGDB
WDTC1
Tbio
Novelty:  0.02300849
p_int:  0.998649997
p_ni:  0.001349412
p_wrong:  5.91e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
LRRN2
Tdark
Novelty:  0.22583761
p_int:  0.980207205
p_ni:  0.01733158
p_wrong:  0.002461215
Score:  0.274
Data Source:  BioPlex,STRINGDB
NOCT
Tbio
Novelty:  0.01696096
p_int:  0.961911935
p_ni:  0.038088064
p_wrong:  1e-9
Data Source:  BioPlex
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
p_int:  0.956905776
p_ni:  0.042967541
p_wrong:  0.000126683
Data Source:  BioPlex
NAPRT
Tchem
Family:  Enzyme
Novelty:  0.0307992
p_int:  0.933196167
p_ni:  0.064562227
p_wrong:  0.002241606
Score:  0.27
Data Source:  BioPlex,STRINGDB
EVA1C
Tbio
Novelty:  0.45928677
p_int:  0.86981972
p_ni:  0.12034
p_wrong:  0.00984028
Score:  0.16
Data Source:  BioPlex,STRINGDB
PCYT2
Tbio
Family:  Enzyme
Novelty:  0.03267621
Score:  0.967
Data Source:  STRINGDB
ETNPPL
Tbio
Family:  Enzyme
Novelty:  0.11207676
Score:  0.925
Data Source:  STRINGDB
Pathways (23)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PE
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PE
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
4
3
4
65.6
neuroticism measurement
2
3
2
5.7
62.6
depressive symptom measurement
1
2
2
52
refractive error measurement
1
1
1
36.9
triglyceride measurement
1
1
1
8.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
4
65.6
neuroticism measurement
2
5.7
62.6
depressive symptom measurement
2
52
refractive error measurement
1
36.9
triglyceride measurement
1
8.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ethanolamine kinase 1
VGNC:13059
101057524
Macaque
ethanolamine kinase 1
707177
Mouse
MGI:1922570
75320
Rat
RGD:1308204
312828
Dog
ethanolamine kinase 1
VGNC:40492
486637
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ethanolamine kinase 1
Macaque
ethanolamine kinase 1
Mouse
Rat
Dog
ethanolamine kinase 1
Publication Statistics
PubMed Score 22.76
PubMed score by year
PubTator Score 6.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title