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Tbio
ETHE1
Persulfide dioxygenase ETHE1, mitochondrial

Protein Summary
Description
Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897). This gene encodes a member of the metallo beta-lactamase family of iron-containing proteins involved in the mitochondrial sulfide oxidation pa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292147
  • ENSP00000292147
  • ENSG00000105755

Symbol
  • HSCO
  • HSCO
  • YF13H12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
tissue sample
0.58
cellular component
0.55
disease
0.55
transcription factor
0.54


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.58   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.58   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.999959661
p_ni:  0.000039148
p_wrong:  0.00000119
Score:  0.187
Data Source:  BioPlex,STRINGDB
SUOX
Tbio
Family:  Enzyme
Novelty:  0.00971136
Score:  0.986
Data Source:  STRINGDB
SQOR
Tchem
Family:  Enzyme
Novelty:  0.00291617
Score:  0.98
Data Source:  Reactome,STRINGDB
TST
Tchem
Family:  Enzyme
Novelty:  0.00214991
Score:  0.972
Data Source:  STRINGDB
MPST
Tchem
Family:  Enzyme
Novelty:  0.00611672
Score:  0.96
Data Source:  STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
Score:  0.782
Data Source:  STRINGDB
PHLDB3
Tdark
Novelty:  2.01921901
Score:  0.768
Data Source:  STRINGDB
ZNF574
Tdark
Family:  TF
Novelty:  2.72596185
Score:  0.75
Data Source:  STRINGDB
TMEM145
Tdark
Novelty:  2.30428448
Score:  0.745
Data Source:  STRINGDB
LRPPRC
Tbio
Novelty:  0.01573276
Score:  0.711
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Degradation of cysteine and homocysteine (R-HSA-1614558)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of cysteine and homocysteine
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Sulfide oxidation to sulfate
Reactome
Sulfur amino acid metabolism
Name
Explore in Pharos
Explore in Source
Degradation of cysteine and homocysteine
Metabolism
Metabolism of amino acids and derivatives
Sulfide oxidation to sulfate
Sulfur amino acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
2
2
68
low density lipoprotein cholesterol measurement
3
3
3
64.9
body height
1
1
1
38.2
cotinine glucuronidation measurement
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
68
low density lipoprotein cholesterol measurement
3
64.9
body height
1
38.2
cotinine glucuronidation measurement
1
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ETHE1, persulfide dioxygenase
VGNC:10246
456093
Macaque
ETHE1, persulfide dioxygenase
718089
Mouse
MGI:1913321
66071
Rat
RGD:1311034
292710
Dog
ETHE1, persulfide dioxygenase
VGNC:40491
612416
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ETHE1, persulfide dioxygenase
Macaque
ETHE1, persulfide dioxygenase
Mouse
Rat
Dog
ETHE1, persulfide dioxygenase
Publication Statistics
PubMed Score 79.58
PubMed score by year
PubTator Score 45.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title