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Tdark
ETFRF1
Electron transfer flavoprotein regulatory factor 1

Protein Summary
Description
Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381356
  • ENSP00000370761
  • ENSG00000205707

Symbol
  • LYRM5
  • LYRM5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.41   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.41   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
ETFA
Tbio
Novelty:  0.00193499
p_int:  1
Score:  0.919
Data Source:  BioPlex,STRINGDB
ETFB
Tchem
Novelty:  0.02010772
p_int:  0.999999994
p_ni:  6e-9
Score:  0.552
Data Source:  BioPlex,STRINGDB
NDUFAB1
Tclin
Novelty:  0.00190242
p_int:  0.99999996
p_ni:  4e-8
Score:  0.914
Data Source:  BioPlex,STRINGDB
MRPL46
Tdark
Novelty:  0.6199259
p_int:  0.999999202
p_ni:  7.98e-7
Score:  0.738
Data Source:  BioPlex,STRINGDB
NADK2
Tbio
Family:  Kinase
Novelty:  0.12395524
p_int:  0.936142663
p_ni:  0.063857337
Score:  0.359
Data Source:  BioPlex,STRINGDB
SPATA20
Tdark
Novelty:  0.34126403
p_int:  0.895846946
p_ni:  0.104153054
Score:  0.179
Data Source:  BioPlex,STRINGDB
NT5DC2
Tbio
Family:  Enzyme
Novelty:  0.18487271
p_int:  0.865519086
p_ni:  0.134480914
Score:  0.345
Data Source:  BioPlex,STRINGDB
EVL
Tbio
Novelty:  0.03533257
p_int:  0.858035903
p_ni:  0.000218141
p_wrong:  0.141745956
Score:  0.179
Data Source:  BioPlex,STRINGDB
CCZ1B
Tdark
Novelty:  0.09724624
p_int:  0.800448
p_ni:  0.199552
Score:  0.188
Data Source:  BioPlex,STRINGDB
KLHL22
Tbio
Novelty:  0.24456252
p_int:  0.781292805
p_ni:  0.218707195
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
74.3
sex hormone-binding globulin measurement
6
1
6
42.1
testosterone measurement
1
1
1
21.3
low density lipoprotein cholesterol measurement
1
1
1
11.1
serum albumin measurement
1
1
1
10.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
74.3
sex hormone-binding globulin measurement
6
42.1
testosterone measurement
1
21.3
low density lipoprotein cholesterol measurement
1
11.1
serum albumin measurement
1
10.3
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914886
67636
Rat
RGD:2320673
100361188
Dog
electron transfer flavoprotein regulatory factor 1
VGNC:40490
477669
Horse
electron transfer flavoprotein regulatory factor 1
VGNC:17697
100629790
Cow
electron transfer flavoprotein regulatory factor 1
VGNC:28622
783110
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
electron transfer flavoprotein regulatory factor 1
Horse
electron transfer flavoprotein regulatory factor 1
Cow
electron transfer flavoprotein regulatory factor 1
Publication Statistics
PubMed Score 0.41
PubMed score by year
PubTator Score 0.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title