You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ETF1
Eukaryotic peptide chain release factor subunit 1

Protein Summary
Description
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360541
  • ENSP00000353741
  • ENSG00000120705
  • ENST00000499810
  • ENSP00000421288

Symbol
  • ERF1
  • RF1
  • SUP45L1
  • ERF
  • RF1
  • ERF1
  • TB3-1
  • D5S1995
  • SUP45L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
transcription factor perturbation
0.99
interacting protein
0.98
transcription factor binding site profile
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.99   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.99   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (391)
GSPT2
Tchem
Family:  Enzyme
Novelty:  0.08140512
p_int:  0.999147485
p_ni:  0.000852515
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.973246883
p_ni:  0.026753117
Score:  0.291
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.969220212
p_ni:  0.030779788
Score:  0.163
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.964207984
p_ni:  0.035792016
Score:  0.207
Data Source:  BioPlex,STRINGDB
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.941360204
p_ni:  0.058639796
Data Source:  BioPlex
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.890826847
p_ni:  0.109173153
Score:  0.753
Data Source:  BioPlex,STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.880709529
p_ni:  0.119290468
p_wrong:  3e-9
Data Source:  BioPlex
SLC38A7
Tdark
Family:  Transporter
Novelty:  0.24353276
p_int:  0.875324373
p_ni:  0.124675627
Score:  0.219
Data Source:  BioPlex,STRINGDB
RNF26
Tbio
Novelty:  0.40088751
p_int:  0.839523248
p_ni:  0.160476752
Score:  0.211
Data Source:  BioPlex,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.832696645
p_ni:  0.167303352
p_wrong:  3e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Eukaryotic Translation Termination
Reactome
Metabolism of RNA
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Eukaryotic Translation Termination
Metabolism of RNA
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
7
3
1
1.1
79
sex hormone-binding globulin measurement
4
1
4
69.3
testosterone measurement
2
2
2
62.1
1
2
0
1.1
51.2
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
1
1.1
79
sex hormone-binding globulin measurement
4
69.3
testosterone measurement
2
62.1
0
1.1
51.2
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation termination factor 1
VGNC:3980
462098
Macaque
eukaryotic translation termination factor 1
714449
Mouse
MGI:2385071
225363
Rat
RGD:1305712
307503
Dog
eukaryotic translation termination factor 1
608717
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation termination factor 1
Macaque
eukaryotic translation termination factor 1
Mouse
Rat
Dog
eukaryotic translation termination factor 1
Publication Statistics
PubMed Score 200.99
PubMed score by year
PubTator Score 156.38
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title