Tbio ETF1 Eukaryotic peptide chain release factor subunit 1

Protein Summary

Description

Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• P62495
• B2R6B4
• D3DQC1
• P46055
• Q5M7Z7
• Q96CG1
• Eukaryotic release factor 1

Gene Name

• ETF1

Ensembl ID

• ENST00000360541
• ENSP00000353741
• ENSG00000120705
• ENST00000499810
• ENSP00000421288

Symbol

• ERF1
• RF1
• SUP45L1
• ERF
• RF1
• ERF1
• TB3-1
• D5S1995
• SUP45L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
virus perturbation	1
transcription factor perturbation	0.99
interacting protein	0.98
transcription factor binding site profile	0.92

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Release Factor / Eukaryotic Peptide Chain Release Factor Subunit 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Release Factor / Eukaryotic Peptide Chain Release Factor Subunit 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.99   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.99   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0