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Tbio
ESYT3
Extended synaptotagmin-3

Protein Summary
Description
Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389567
  • ENSP00000374218
  • ENSG00000158220
  • ENST00000490835
  • ENSP00000417388

Symbol
  • FAM62C
  • E-Syt3
  • FAM62C
  • CHR3SYT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.74
histone modification site profile
0.73
gene perturbation
0.68
microRNA
0.64
tissue
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.98   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.98   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
ESYT1
Tbio
Novelty:  0.03069611
Score:  0.944
Data Source:  Reactome,STRINGDB
ESYT2
Tbio
Novelty:  0.04545794
Score:  0.941
Data Source:  Reactome,STRINGDB
SYT16
Tbio
Novelty:  0.05270686
Score:  0.675
Data Source:  STRINGDB
SLC12A8
Tbio
Family:  Transporter
Novelty:  0.06012072
Score:  0.674
Data Source:  STRINGDB
SYT14
Tbio
Novelty:  0.0413313
Score:  0.663
Data Source:  STRINGDB
SYT15
Tdark
Novelty:  0.05347364
Score:  0.654
Data Source:  STRINGDB
RMDN3
Tbio
Novelty:  0.05108761
Score:  0.652
Data Source:  STRINGDB
SYT13
Tbio
Novelty:  0.03332595
Score:  0.598
Data Source:  STRINGDB
REEP5
Tbio
Novelty:  0.00160455
Score:  0.562
Data Source:  STRINGDB
STIMATE
Tbio
Novelty:  0.28975783
Score:  0.554
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Glycosphingolipid metabolism (R-HSA-1660662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
6
4
1.1
91.1
BMI-adjusted waist-hip ratio
2
3
3
81.4
waist circumference
1
2
2
80.6
waist-hip ratio
1
2
2
77.4
testosterone measurement
2
2
2
76.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
91.1
BMI-adjusted waist-hip ratio
3
81.4
waist circumference
2
80.6
waist-hip ratio
2
77.4
testosterone measurement
2
76.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
extended synaptotagmin 3
VGNC:7060
460726
Mouse
MGI:1098699
272636
Rat
RGD:1561304
363120
Dog
extended synaptotagmin 3
VGNC:40485
485686
Cow
extended synaptotagmin 3
VGNC:28615
530157
Species
Name
OMA
EggNOG
Inparanoid
Chimp
extended synaptotagmin 3
Mouse
Rat
Dog
extended synaptotagmin 3
Cow
extended synaptotagmin 3
Publication Statistics
PubMed Score 9.98
PubMed score by year
PubTator Score 2.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title