Tbio ESYT3 Extended synaptotagmin-3

Protein Summary

Description

Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.

Uniprot Accession IDs

• A0FGR9
• A8K0G5
• Q6ZV21
• Q8NDZ5
• Q9BQR9
• E-Syt3

Gene Name

• ESYT3

Ensembl ID

• ENST00000389567
• ENSP00000374218
• ENSG00000158220
• ENST00000490835
• ENSP00000417388

Symbol

• FAM62C
• E-Syt3
• FAM62C
• CHR3SYT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.74
histone modification site profile	0.73
gene perturbation	0.68
microRNA	0.64
tissue	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.98   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 59   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.98   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (42)

Explore Interacting Targets

1 – 10 of 42

• See Interactions on String-DB

ESYT1

Tbio

Novelty:  0.03069611

Score:  0.944

Data Source:  Reactome,STRINGDB

ESYT2

Tbio

Novelty:  0.04545794

Score:  0.941

Data Source:  Reactome,STRINGDB

SYT16

Tbio

Novelty:  0.05270686

Score:  0.675

Data Source:  STRINGDB

SLC12A8

Tbio

Family:  Transporter

Novelty:  0.06012072

Score:  0.674

Data Source:  STRINGDB

SYT14

Tbio

Novelty:  0.0413313

Score:  0.663

Data Source:  STRINGDB

SYT15

Tdark

Novelty:  0.05347364

Score:  0.654

Data Source:  STRINGDB

RMDN3

Tbio

Novelty:  0.05108761

Score:  0.652

Data Source:  STRINGDB

SYT13

Tbio

Novelty:  0.03332595

Score:  0.598

Data Source:  STRINGDB

REEP5

Tbio

Novelty:  0.00160455

Score:  0.562

Data Source:  STRINGDB

STIMATE

Tbio

Novelty:  0.28975783

Score:  0.554

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (4)

Glycosphingolipid metabolism (R-HSA-1660662)

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Find Similar Targets

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Sphingolipid metabolism	90 targets	R-HSA-428157

Name	Explore in Pharos	Explore in Source
Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Sphingolipid metabolism	90 targets	R-HSA-428157

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (5)

Components (6)

Processes (2)

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1 – 5 of 5

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
calcium-dependent phospholipid binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphatidylcholine binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphatidylethanolamine binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphatidylinositol binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (17)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 17

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
coronary artery disease	EFO_0001645	8	6	4	1.1	91.1
BMI-adjusted waist-hip ratio	EFO_0007788	2	3	3		81.4
waist circumference	EFO_0004342	1	2	2		80.6
waist-hip ratio	EFO_0004343	1	2	2		77.4
testosterone measurement	EFO_0004908	2	2	2		76.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 17

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
coronary artery disease	EFO_0001645	4	1.1	91.1
BMI-adjusted waist-hip ratio	EFO_0007788	3		81.4
waist circumference	EFO_0004342	2		80.6
waist-hip ratio	EFO_0004343	2		77.4
testosterone measurement	EFO_0004908	2		76.5

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Calcium
Cell membrane
Complete proteome
Endoplasmic reticulum
Lipid transport
Lipid-binding
Membrane
Metal-binding
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
Agents acting on the renin-angiotensin system use measurement
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
body mass index
chronotype measurement
comparative body size at age 10, self-reported
coronary artery disease
hair color
Hodgkins lymphoma
mathematical ability

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
hematopoietic system phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	extended synaptotagmin 3	VGNC:7060	460726
Mouse	extended synaptotagmin-like protein 3	MGI:1098699	272636
Rat	extended synaptotagmin 3	RGD:1561304	363120
Dog	extended synaptotagmin 3	VGNC:40485	485686
Cow	extended synaptotagmin 3	VGNC:28615	530157

Species	Name	OMA	EggNOG	Inparanoid
Chimp	extended synaptotagmin 3
Mouse	extended synaptotagmin-like protein 3
Rat	extended synaptotagmin 3
Dog	extended synaptotagmin 3
Cow	extended synaptotagmin 3

Publication Statistics

PubMed Score 9.98

PubMed score by year

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PubTator Score 2.56

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (3)

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PMID	Year	Title