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Tbio
ESS2
Splicing factor ESS-2 homolog

Protein Summary
Description
May be involved in pre-mRNA splicing. This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252137
  • ENSP00000252137
  • ENSG00000100056

Symbol
  • DGCR13
  • DGCR14
  • DGSH
  • DGSI
  • ES2
  • ES2
  • DGSH
  • DGSI
  • bis1
  • DGS-H
  • DGS-I
  • ESS-2
  • Es2el
  • DGCR13
  • DGCR14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1106.78   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1106.78   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
HINT3
Tdark
Novelty:  1.14285714
p_int:  0.99988837
p_ni:  0.00011163
Data Source:  BioPlex
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999788272
p_ni:  0.000211714
p_wrong:  1.4e-8
Data Source:  BioPlex
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.999476829
p_ni:  0.00052315
p_wrong:  2.1e-8
Data Source:  BioPlex
BCAS2
Tbio
Novelty:  0.05425016
p_int:  0.999437591
p_ni:  0.000562409
Data Source:  BioPlex
FAM170A
Tdark
Novelty:  0.05778712
p_int:  0.999410785
p_ni:  0.000589215
Data Source:  BioPlex
FRA10AC1
Tbio
Novelty:  0.25570773
p_int:  0.998623885
p_ni:  0.001374666
p_wrong:  0.000001448
Score:  0.828
Data Source:  BioPlex,STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.996906487
p_ni:  0.003093513
Score:  0.892
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.996729873
p_ni:  0.003270124
p_wrong:  3e-9
Data Source:  BioPlex
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.99633328
p_ni:  0.003666718
p_wrong:  3e-9
Score:  0.216
Data Source:  BioPlex,STRINGDB
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.996081389
p_ni:  0.003918611
Score:  0.466
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
citrate measurement
2
3
3
87.9
blood metabolite measurement
1
1
1
52
amino acid measurement
1
1
1
52
protein measurement
1
1
1
52
glomerular filtration rate
2
2
2
50.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
citrate measurement
3
87.9
blood metabolite measurement
1
52
amino acid measurement
1
52
protein measurement
1
52
glomerular filtration rate
2
50.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ess-2 splicing factor homolog
VGNC:14855
458954
Macaque
ess-2 splicing factor homolog
711157
Mouse
MGI:107854
27886
Rat
RGD:1308218
360741
Dog
ess-2 splicing factor homolog
VGNC:40482
486425
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ess-2 splicing factor homolog
Macaque
ess-2 splicing factor homolog
Mouse
Rat
Dog
ess-2 splicing factor homolog
Publication Statistics
PubMed Score 1106.78
PubMed score by year
PubTator Score 147.46
PubTator score by year
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Related Publications
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PMID
Year
Title