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Tclin
ESR2
Estrogen receptor beta

Protein Summary
Description
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact w ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267525
  • ENSP00000267525
  • ENSG00000140009
  • ENST00000341099
  • ENSP00000343925
  • ENST00000344288
  • ENSP00000345616
  • ENST00000353772
  • ENSP00000335551
  • ENST00000358599
  • ENSP00000351412
  • ENST00000553796
  • ENSP00000452426
  • ENST00000554572
  • ENSP00000450699
  • ENST00000555278
  • ENSP00000450488
  • ENST00000557772
  • ENSP00000451582

Symbol
  • ESTRB
  • NR3A2
  • Erb
  • ESRB
  • ODG8
  • ESTRB
  • NR3A2
  • ER-BETA
  • ESR-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
hub protein
1
molecular function
1
drug
0.97
protein domain
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4609.68   (req: < 5)
Gene RIFs: 901   (req: <= 3)
Antibodies: 1609   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4609.68   (req: >= 5)
Gene RIFs: 901   (req: > 3)
Antibodies: 1609   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1066
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 17