Protein Summary
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B resp ...more
- ENST00000206249
- ENSP00000206249
- ENSG00000091831
- ENST00000338799
- ENSP00000342630
- ENST00000440973
- ENSP00000405330
- ENST00000443427
- ENSP00000387500
- ESR
- NR3A1
- ER
- ESR
- Era
- ESRA
- ESTRR
- NR3A1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
drug | 1 | ||
hub protein | 1 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15920.85 (req: < 5)
Gene RIFs: 2353 (req: <= 3)
Antibodies: 3731 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15920.85 (req: >= 5)
Gene RIFs: 2353 (req: > 3)
Antibodies: 3731 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 72
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1443
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 27
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (27)
Active Ligands (1443)
Protein-Protein Interactions (861)
PPP1R14C
Family: Enzyme
Novelty: 0.04635786
p_int: 0.999521064
p_ni: 0.000469328
p_wrong: 0.000009608
Score: 0.379
Data Source: BioPlex,STRINGDB
GBP1
Novelty: 0.00634662
p_int: 0.999302822
p_ni: 0.000697103
p_wrong: 7.5e-8
Score: 0.284
Data Source: BioPlex,STRINGDB
PGK2
Family: Kinase
Novelty: 0.00832045
p_int: 0.997760062
p_ni: 0.002239523
p_wrong: 4.15e-7
Score: 0.163
Data Source: BioPlex,STRINGDB
SIGLEC10
Novelty: 0.02858542
p_int: 0.993513533
p_ni: 0.006486467
Score: 0.345
Data Source: BioPlex,STRINGDB
PNMT
Family: Enzyme
Novelty: 0.00178141
p_int: 0.929202421
p_ni: 0.042326228
p_wrong: 0.028471351
Score: 0.555
Data Source: BioPlex,STRINGDB
CNDP1
Family: Enzyme
Novelty: 0.0102642
p_int: 0.901555575
p_ni: 0.098441636
p_wrong: 0.00000279
Score: 0.194
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (69)
Reactome (34)
KEGG (8)
PathwayCommons (16)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Reactome | Deubiquitination | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | ESR-mediated signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Deubiquitination | ||||
Disease | ||||
Diseases of signal transduction | ||||
ESR-mediated signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (84)
Functions (23)
Components (12)
Processes (49)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Disease Associations (null)
GWAS Traits (39)
Items per page:
1 – 5 of 39
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 18 | 35 | 99.9 | |||||
bone density | 12 | 13 | 20 | 97.2 | |||||
body height | 5 | 4 | 6 | 96.6 | |||||
2 | 5 | 0 | 1.2 | 96.2 | |||||
13 | 11 | 0 | 1.2 | 95.3 | |||||
Items per page:
1 – 5 of 39
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 35 | 99.9 | |||||
bone density | 20 | 97.2 | |||||
body height | 6 | 96.6 | |||||
0 | 1.2 | 96.2 | |||||
0 | 1.2 | 95.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | estrogen receptor 1 | VGNC:2781 | 463079 | |||||
Macaque | estrogen receptor 1 | 613025 | ||||||
Mouse | MGI:1352467 | 13982 | ||||||
Rat | RGD:2581 | 24890 | ||||||
Dog | estrogen receptor 1 | VGNC:40476 | 403640 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | estrogen receptor 1 | |||||
Macaque | estrogen receptor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | estrogen receptor 1 | |||||
Publication Statistics
PubMed Score 15920.85
PubMed score by year
PubTator Score 12162.96
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (2853)
GeneRif Annotations (2353)
Items per page:
0 of 0
PMID | Year | Title |
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