ESD
S-formylglutathione hydrolase
Protein Summary
Serine hydrolase involved in the detoxification of formaldehyde. This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a genetic marker for retinoblastoma and Wilson's disease. [provided by RefSeq, Feb 2009]
- ENST00000378720
- ENSP00000367992
- ENSG00000139684
- FGH
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
transcription factor perturbation | 1 | ||
co-expressed gene | 0.95 | ||
virus perturbation | 0.85 | ||
interacting protein | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 346.1 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 198 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 346.1 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 198 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0