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Tbio
ESAM
Endothelial cell-selective adhesion molecule

Protein Summary
Description
Can mediate aggregation most likely through a homophilic molecular interaction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278927
  • ENSP00000278927
  • ENSG00000149564
  • ENST00000444566
  • ENSP00000406689

Symbol
  • W117m
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor perturbation
0.8
protein domain
0.73
tissue sample
0.65
cellular component
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.37   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.37   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
MPHOSPH8
Tbio
Family:  Epigenetic
Novelty:  0.0534439
p_int:  0.986520347
p_ni:  0.000389102
p_wrong:  0.01309055
Score:  0.54
Data Source:  BioPlex,STRINGDB
TOP1
Tclin
Family:  Enzyme
Novelty:  0.00019573
p_int:  0.952336066
p_ni:  0.047663934
Score:  0.19
Data Source:  BioPlex,STRINGDB
MDC1
Tbio
Novelty:  0.00533097
p_int:  0.881715791
p_ni:  0.118283918
p_wrong:  2.92e-7
Score:  0.252
Data Source:  BioPlex,STRINGDB
CENPF
Tbio
Novelty:  0.00676983
p_int:  0.860539587
p_ni:  0.139460412
p_wrong:  1e-9
Score:  0.243
Data Source:  BioPlex,STRINGDB
SELPLG
Tbio
Novelty:  0.0016359
Score:  0.923
Data Source:  Reactome,STRINGDB
CLDN5
Tbio
Novelty:  0.00174396
Score:  0.828
Data Source:  STRINGDB
OCLN
Tbio
Novelty:  0.00047671
Score:  0.772
Data Source:  STRINGDB
CLCA2
Tbio
Family:  IC
Novelty:  0.0306541
Score:  0.751
Data Source:  STRINGDB
DCBLD2
Tbio
Novelty:  0.06514947
Score:  0.745
Data Source:  STRINGDB
PECAM1
Tbio
Novelty:  0.00013373
Score:  0.721
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
1
1
60.2
8
1
2
1.1
57.3
1
1
0
1.1
56.8
self reported educational attainment
1
1
1
40.7
intelligence
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
60.2
2
1.1
57.3
0
1.1
56.8
self reported educational attainment
1
40.7
intelligence
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endothelial cell adhesion molecule
VGNC:11768
451639
Macaque
endothelial cell adhesion molecule
712200
Mouse
MGI:1916774
69524
Rat
RGD:1303286
300519
Dog
endothelial cell adhesion molecule
VGNC:53356
489309
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endothelial cell adhesion molecule
Macaque
endothelial cell adhesion molecule
Mouse
Rat
Dog
endothelial cell adhesion molecule
Publication Statistics
PubMed Score 142.37
PubMed score by year
PubTator Score 39.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title