Tbio ESAM Endothelial cell-selective adhesion molecule

Protein Summary

Description

Can mediate aggregation most likely through a homophilic molecular interaction.

Uniprot Accession IDs

• Q96AP7
• B4DVN8
• Q96T50

Gene Name

• ESAM

Ensembl ID

• ENST00000278927
• ENSP00000278927
• ENSG00000149564
• ENST00000444566
• ENSP00000406689

Symbol

• W117m

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.88
transcription factor perturbation	0.8
protein domain	0.73
tissue sample	0.65
cellular component	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.37   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 403   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.37   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (68)

Explore Interacting Targets

1 – 10 of 68

• See Interactions on String-DB

MPHOSPH8

Tbio

Family:  Epigenetic

Novelty:  0.0534439

p_int:  0.986520347

p_ni:  0.000389102

p_wrong:  0.01309055

Score:  0.54

Data Source:  BioPlex,STRINGDB

TOP1

Tclin

Family:  Enzyme

Novelty:  0.00019573

p_int:  0.952336066

p_ni:  0.047663934

Score:  0.19

Data Source:  BioPlex,STRINGDB

MDC1

Tbio

Novelty:  0.00533097

p_int:  0.881715791

p_ni:  0.118283918

p_wrong:  2.92e-7

Score:  0.252

Data Source:  BioPlex,STRINGDB

CENPF

Tbio

Novelty:  0.00676983

p_int:  0.860539587

p_ni:  0.139460412

p_wrong:  1e-9

Score:  0.243

Data Source:  BioPlex,STRINGDB

SELPLG

Tbio

Novelty:  0.0016359

Score:  0.923

Data Source:  Reactome,STRINGDB

CLDN5

Tbio

Novelty:  0.00174396

Score:  0.828

Data Source:  STRINGDB

OCLN

Tbio

Novelty:  0.00047671

Score:  0.772

Data Source:  STRINGDB

CLCA2

Tbio

Family:  IC

Novelty:  0.0306541

Score:  0.751

Data Source:  STRINGDB

DCBLD2

Tbio

Novelty:  0.06514947

Score:  0.745

Data Source:  STRINGDB

PECAM1

Tbio

Novelty:  0.00013373

Score:  0.721

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (2)

KEGG (2)

Cell surface interactions at the vascular wall (R-HSA-202733)

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Find Similar Targets

Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Hemostasis	666 targets	R-HSA-109582

Name	Explore in Pharos	Explore in Source
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Hemostasis	666 targets	R-HSA-109582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Components (4)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
plasma membrane	Traceable Author Statement (TAS)	Reactome
adherens junction	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
bicellular tight junction	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum metabolite measurement	EFO_0005653	1	1	1		60.2
schizophrenia	EFO_0000692	8	1	2	1.1	57.3
autism spectrum disorder	EFO_0003756	1	1	0	1.1	56.8
self reported educational attainment	EFO_0004784	1	1	1		40.7
intelligence	EFO_0004337	1	1	1		40.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum metabolite measurement	EFO_0005653	1		60.2
schizophrenia	EFO_0000692	2	1.1	57.3
autism spectrum disorder	EFO_0003756	0	1.1	56.8
self reported educational attainment	EFO_0004784	1		40.7
intelligence	EFO_0004337	1		40.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell adhesion
Cell junction
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
autism spectrum disorder
intelligence
schizophrenia
self reported educational attainment
serum metabolite measurement
smoking status measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
neoplasm

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	endothelial cell adhesion molecule	VGNC:11768	451639
Macaque	endothelial cell adhesion molecule		712200
Mouse	endothelial cell-specific adhesion molecule	MGI:1916774	69524
Rat	endothelial cell adhesion molecule	RGD:1303286	300519
Dog	endothelial cell adhesion molecule	VGNC:53356	489309

Species	Name	OMA	EggNOG	Inparanoid
Chimp	endothelial cell adhesion molecule
Macaque	endothelial cell adhesion molecule
Mouse	endothelial cell-specific adhesion molecule
Rat	endothelial cell adhesion molecule
Dog	endothelial cell adhesion molecule

Publication Statistics

PubMed Score 142.37

PubMed score by year

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PubTator Score 39.83

PubTator score by year

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Related Publications

Text Mined References (20)

GeneRif Annotations (7)

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10

0 of 0

PMID	Year	Title