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Tbio
ERVW-1
Syncytin-1

Protein Summary
Description
This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904). Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomai ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000493463
  • ENSP00000419945
  • ENSG00000242950
  • ENST00000603053
  • ENSP00000474984

Symbol
  • ERVWE1
  • ENV
  • ENVW
  • HERVW
  • ERVWE1
  • HERV7Q
  • HERV-7q
  • HERVWENV
  • HERV-W-ENV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.71
biological term
0.69
cell line
0.69
disease
0.67
cellular component
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2200.62   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2200.62   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
ITIH4
Tbio
Novelty:  0.00032471
Score:  0.953
Data Source:  STRINGDB
CCR5
Tclin
Family:  GPCR
Novelty:  0.00022549
Score:  0.892
Data Source:  STRINGDB
EMB
Tbio
Novelty:  0.00135577
Score:  0.866
Data Source:  STRINGDB
S100B
Tchem
Novelty:  0.00031007
Score:  0.86
Data Source:  STRINGDB
GCM1
Tbio
Family:  TF
Novelty:  0.01067683
Score:  0.849
Data Source:  STRINGDB
CXCR4
Tclin
Family:  GPCR
Novelty:  0.0002811
Score:  0.833
Data Source:  STRINGDB
CD4
Tclin
Novelty:  0.00001217
Score:  0.799
Data Source:  STRINGDB
SCD5
Tchem
Family:  Enzyme
Novelty:  0.00337317
Score:  0.71
Data Source:  STRINGDB
GYPC
Tbio
Novelty:  0.00138506
Score:  0.706
Data Source:  STRINGDB
SLC1A5
Tchem
Family:  Transporter
Novelty:  0.00201741
Score:  0.703
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
7
9
88.9
lymphocyte count
1
1
1
12.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
9
88.9
lymphocyte count
1
12.6
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 2200.62
PubMed score by year
PubTator Score 538.72
PubTator score by year
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Related Publications
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PMID
Year
Title