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Tdark
ERVMER34-1
Endogenous retroviral envelope protein HEMO

Protein Summary
Description
Endogenous envelope proteins originate from retroviral envelope proteins, which mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000440542
  • ENSP00000460255
  • ENSG00000226887
  • ENST00000443173
  • ENSP00000460602

Symbol
  • HEMO
  • HEMO
  • envMER34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.79
histone modification site profile
0.65
cell type or tissue
0.63
tissue
0.61
cell line
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.5   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.5   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (10)
STK10
Tchem
Family:  Kinase
Novelty:  0.01536884
Score:  0.926
Data Source:  STRINGDB
ERV3-1
Tbio
Novelty:  0.00916582
Score:  0.615
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.588
Data Source:  STRINGDB
SHC4
Tbio
Novelty:  0.04623367
Score:  0.473
Data Source:  STRINGDB
GATA1
Tbio
Family:  TF
Novelty:  0.00077901
Score:  0.47
Data Source:  STRINGDB
ZNF92
Tbio
Family:  TF
Novelty:  0.05724663
Score:  0.429
Data Source:  STRINGDB
CXCR4
Tclin
Family:  GPCR
Novelty:  0.0002811
Score:  0.425
Data Source:  STRINGDB
CRP
Tbio
Novelty:  0.00001517
Score:  0.42
Data Source:  STRINGDB
PAM
Tchem
Family:  Enzyme
Novelty:  0.00378397
Score:  0.406
Data Source:  STRINGDB
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.4
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
1
1
0
26.7
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
26.7
46.5
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
endogenous retrovirus group MER34 member 1, envelope
100429988
Opossum
endogenous retrovirus group MER34 member 1 Env polyprotein-like
103104695
Species
Name
OMA
EggNOG
Inparanoid
Macaque
endogenous retrovirus group MER34 member 1, envelope
Opossum
endogenous retrovirus group MER34 member 1 Env polyprotein-like
Publication Statistics
PubMed Score 29.50
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title