Tbio ERV3-1 Endogenous retrovirus group 3 member 1 Env polyprotein

Protein Summary

Description

Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro. SU mediates receptor recognition. TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). This gene contains sequence derived from endogenous retrovirus, and is therefore similar to multiple other loci in the genome. Transcripts at this locus encode a conserved protein with a predicted signal peptide and similarity to the Env polyprotein. This protein is overexpressed in colorectal and other cancers. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• Q14264

Gene Name

• ERV3-1

Ensembl ID

• ENST00000394323
• ENSP00000391594
• ENSG00000213462

Symbol

• ERV3
• ERV3
• ERVR
• envR
• ERV-R
• HERVR
• HERV-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.76
microRNA	0.67
tissue sample	0.64
transcription factor	0.53
cell line	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.94   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.94   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0