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Tbio
ERV3-1
Endogenous retrovirus group 3 member 1 Env polyprotein

Protein Summary
Description
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro. SU mediates receptor recognition. TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). This gene contains sequence derived from endogenous retrovirus, and is therefore similar to multiple other loci in the genome. Transcripts at this locus encode a conserved protein with a predicted signal peptide and similarity to the Env polyprotein. This protein is overexpressed in colorectal and other cancers. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394323
  • ENSP00000391594
  • ENSG00000213462

Symbol
  • ERV3
  • ERV3
  • ERVR
  • envR
  • ERV-R
  • HERVR
  • HERV-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.76
microRNA
0.67
tissue sample
0.64
transcription factor
0.53
cell line
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.94   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.94   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
ZNF117
Tdark
Family:  TF
Novelty:  0.65663286
Score:  0.673
Data Source:  STRINGDB
ERVMER34-1
Tdark
Novelty:  0.03871814
Score:  0.615
Data Source:  STRINGDB
CLEC10A
Tbio
Novelty:  0.00656565
Score:  0.578
Data Source:  STRINGDB
GFER
Tchem
Family:  Enzyme
Novelty:  0.00338563
Score:  0.56
Data Source:  STRINGDB
CYB5R4
Tbio
Family:  Enzyme
Novelty:  0.06424571
Score:  0.535
Data Source:  STRINGDB
TREML1
Tbio
Novelty:  0.03513416
Score:  0.519
Data Source:  STRINGDB
ZNF138
Tdark
Family:  TF
Novelty:  3.68758686
Score:  0.512
Data Source:  STRINGDB
C11orf94
Tdark
Novelty:  126
Score:  0.511
Data Source:  STRINGDB
ZNF550
Tdark
Family:  TF
Novelty:  18
Score:  0.491
Data Source:  STRINGDB
ZNF92
Tbio
Family:  TF
Novelty:  0.05724663
Score:  0.473
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
1
2
77.7
sleep duration
2
1
2
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
77.7
sleep duration
2
77.7
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 134.94
PubMed score by year
PubTator Score 71.22
PubTator score by year
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Related Publications
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PMID
Year
Title