You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ERP44
Endoplasmic reticulum resident protein 44

Protein Summary
Description
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum. This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262455
  • ENSP00000262455
  • ENSG00000023318

Symbol
  • KIAA0573
  • TXNDC4
  • PDIA10
  • TXNDC4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor perturbation
0.94
histone modification site profile
0.89
interacting protein
0.85
tissue
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.47   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.47   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (152)
ZFPM1
Tbio
Family:  TF
Novelty:  0.01061715
p_int:  0.999999982
p_ni:  1.6e-8
p_wrong:  1e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
MEX3A
Tbio
Novelty:  0.10552978
p_int:  0.999999202
p_ni:  7.8e-7
p_wrong:  1.8e-8
Score:  0.325
Data Source:  BioPlex,STRINGDB
STXBP4
Tbio
Novelty:  0.08831326
p_int:  0.999993427
p_ni:  0.000006573
Data Source:  BioPlex
PXDN
Tbio
Novelty:  0.00935722
p_int:  0.999944194
p_ni:  0.000055804
p_wrong:  1e-9
Data Source:  BioPlex
MIGA1
Tbio
Novelty:  0.08346483
p_int:  0.999908407
p_ni:  0.000091585
p_wrong:  8e-9
Data Source:  BioPlex
TGFB1
Tbio
Novelty:  0.0001299
p_int:  0.999902852
p_ni:  0.000097148
Data Source:  BioPlex
DCP1B
Tdark
Novelty:  0.36605365
p_int:  0.999887732
p_ni:  0.000112268
Score:  0.156
Data Source:  BioPlex,STRINGDB
ZNF212
Tdark
Family:  TF
Novelty:  0.68902645
p_int:  0.999780298
p_ni:  0.000219702
Score:  0.337
Data Source:  BioPlex,STRINGDB
DAPK1
Tchem
Family:  Kinase
Novelty:  0.0031894
p_int:  0.99721573
p_ni:  0.000204697
p_wrong:  0.002579574
Score:  0.274
Data Source:  BioPlex,STRINGDB
BCOR
Tbio
Novelty:  0.05718292
p_int:  0.997021099
p_ni:  0.002978888
p_wrong:  1.4e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum protein 44
VGNC:13877
464616
Macaque
endoplasmic reticulum protein 44
100423317
Mouse
MGI:1923549
76299
Rat
RGD:1309176
298066
Dog
endoplasmic reticulum protein 44
VGNC:51716
474781
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum protein 44
Macaque
endoplasmic reticulum protein 44
Mouse
Rat
Dog
endoplasmic reticulum protein 44
Publication Statistics
PubMed Score 45.47
PubMed score by year
PubTator Score 28.27
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title