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Tbio
ERP29
Endoplasmic reticulum resident protein 29

Protein Summary
Description
Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER. This gene encodes a protein which localizes to the lumen of the endoplasmic reticulum (ER). It is a member of the protein disulfide isomerase (PDI) protein family but lacks an active thioredoxin motif, suggesting that this protein does not function as a disulfide isomerase. The canonical protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261735
  • ENSP00000261735
  • ENSG00000089248
  • ENST00000455836
  • ENSP00000412083

Symbol
  • C12orf8
  • ERP28
  • ERp28
  • ERp31
  • PDIA9
  • PDI-DB
  • C12orf8
  • HEL-S-107
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.93
histone modification site profile
0.87
transcription factor binding site profile
0.86
cellular component
0.85


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.64   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.64   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
GLB1L
Tdark
Family:  Enzyme
Novelty:  0.43027328
p_int:  0.99999974
p_ni:  1.73e-7
p_wrong:  8.8e-8
Score:  0.269
Data Source:  BioPlex,STRINGDB
ALDH16A1
Tdark
Family:  Enzyme
Novelty:  0.21880567
p_int:  0.999869135
p_ni:  0.000130865
Score:  0.211
Data Source:  BioPlex,STRINGDB
ARSB
Tbio
Family:  Enzyme
Novelty:  0.01044355
p_int:  0.999677985
p_ni:  0.000321886
p_wrong:  1.3e-7
Score:  0.273
Data Source:  BioPlex,STRINGDB
DERA
Tbio
Family:  Enzyme
Novelty:  0.0079635
p_int:  0.999558238
p_ni:  0.000441762
Score:  0.345
Data Source:  BioPlex,STRINGDB
EXOC5
Tbio
Novelty:  0.02200205
p_int:  0.99691438
p_ni:  0.003085611
p_wrong:  9e-9
Data Source:  BioPlex
HLA-DPB1
Tbio
Novelty:  0.00185371
p_int:  0.826955056
p_ni:  0.173044944
Score:  0.188
Data Source:  BioPlex,STRINGDB
CYP2S1
Tbio
Novelty:  0.02967417
Score:  0.8
Data Source:  STRINGDB
HSPB1
Tchem
Novelty:  0.00081373
Score:  0.774
Data Source:  STRINGDB
EDEM3
Tbio
Family:  Enzyme
Novelty:  0.09828323
Score:  0.772
Data Source:  STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
Score:  0.769
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
3
3
96.1
platelet crit
2
2
2
93.5
body weight
1
2
2
85.2
energy intake
1
1
0
1.8
79.7
1
1
0
2.4
78.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
96.1
platelet crit
2
93.5
body weight
2
85.2
energy intake
0
1.8
79.7
0
2.4
78.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum protein 29
VGNC:5368
738376
Mouse
MGI:1914647
67397
Rat
RGD:619781
117030
Dog
endoplasmic reticulum protein 29
VGNC:40468
477482
Horse
endoplasmic reticulum protein 29
VGNC:17675
100057258
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum protein 29
Mouse
Rat
Dog
endoplasmic reticulum protein 29
Horse
endoplasmic reticulum protein 29
Publication Statistics
PubMed Score 93.64
PubMed score by year
PubTator Score 49.66
PubTator score by year
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Related Publications
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PMID
Year
Title