ERP29
Endoplasmic reticulum resident protein 29
Protein Summary
Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER. This gene encodes a protein which localizes to the lumen of the endoplasmic reticulum (ER). It is a member of the protein disulfide isomerase (PDI) protein family but lacks an active thioredoxin motif, suggesting that this protein does not function as a disulfide isomerase. The canonical protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
- ENST00000261735
- ENSP00000261735
- ENSG00000089248
- ENST00000455836
- ENSP00000412083
- C12orf8
- ERP28
- ERp28
- ERp31
- PDIA9
- PDI-DB
- C12orf8
- HEL-S-107
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
disease perturbation | 0.93 | ||
histone modification site profile | 0.87 | ||
transcription factor binding site profile | 0.86 | ||
cellular component | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 93.64 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 300 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 93.64 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 300 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (52)
GLB1L
Family: Enzyme
Novelty: 0.43027328
p_int: 0.99999974
p_ni: 1.73e-7
p_wrong: 8.8e-8
Score: 0.269
Data Source: BioPlex,STRINGDB
ALDH16A1
Family: Enzyme
Novelty: 0.21880567
p_int: 0.999869135
p_ni: 0.000130865
Score: 0.211
Data Source: BioPlex,STRINGDB
ARSB
Family: Enzyme
Novelty: 0.01044355
p_int: 0.999677985
p_ni: 0.000321886
p_wrong: 1.3e-7
Score: 0.273
Data Source: BioPlex,STRINGDB
DERA
Family: Enzyme
Novelty: 0.0079635
p_int: 0.999558238
p_ni: 0.000441762
Score: 0.345
Data Source: BioPlex,STRINGDB
HLA-DPB1
Novelty: 0.00185371
p_int: 0.826955056
p_ni: 0.173044944
Score: 0.188
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Protein processing in endoplasmic reticulum | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Protein processing in endoplasmic reticulum | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (2)
Components (7)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | ParkinsonsUK-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | ParkinsonsUK-UCL | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 2 | 3 | 3 | 96.1 | |||||
platelet crit | 2 | 2 | 2 | 93.5 | |||||
body weight | 1 | 2 | 2 | 85.2 | |||||
energy intake | 1 | 1 | 0 | 1.8 | 79.7 | ||||
1 | 1 | 0 | 2.4 | 78.3 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 3 | 96.1 | |||||
platelet crit | 2 | 93.5 | |||||
body weight | 2 | 85.2 | |||||
energy intake | 0 | 1.8 | 79.7 | ||||
0 | 2.4 | 78.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | endoplasmic reticulum protein 29 | VGNC:5368 | 738376 | |||||
Mouse | MGI:1914647 | 67397 | ||||||
Rat | RGD:619781 | 117030 | ||||||
Dog | endoplasmic reticulum protein 29 | VGNC:40468 | 477482 | |||||
Horse | endoplasmic reticulum protein 29 | VGNC:17675 | 100057258 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | endoplasmic reticulum protein 29 | |||||
Mouse | ||||||
Rat | ||||||
Dog | endoplasmic reticulum protein 29 | |||||
Horse | endoplasmic reticulum protein 29 | |||||
Publication Statistics
PubMed Score 93.64
PubMed score by year
PubTator Score 49.66
PubTator score by year
Related Publications
Text Mined References (49)
GeneRif Annotations (32)
Items per page:
0 of 0
PMID | Year | Title |
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