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Tbio
ERMP1
Endoplasmic reticulum metallopeptidase 1

Protein Summary
Description
Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339450
  • ENSP00000340427
  • ENSG00000099219
  • ENST00000462592
  • ENSP00000417160

Symbol
  • FXNA
  • KIAA1815
  • FXNA
  • KIAA1815
  • bA207C16.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
histone modification site profile
0.74
transcription factor binding site profile
0.74
microRNA
0.69
cell type or tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.02   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.02   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.999997483
p_ni:  0.000002516
Data Source:  BioPlex
SCGB3A1
Tbio
Novelty:  0.03574127
p_int:  0.998571092
p_ni:  0.001428895
p_wrong:  1.3e-8
Data Source:  BioPlex
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.997728761
p_ni:  0.002271239
Data Source:  BioPlex
GABRE
Tclin
Family:  IC
Novelty:  0.03814541
p_int:  0.997145264
p_ni:  0.002854736
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.996885042
p_ni:  0.003114958
Data Source:  BioPlex
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.990765448
p_ni:  0.009234549
p_wrong:  3e-9
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.989794902
p_ni:  0.010205098
Data Source:  BioPlex
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.98594566
p_ni:  0.014054306
p_wrong:  3.4e-8
Data Source:  BioPlex
C4orf3
Tbio
Novelty:  0.05950373
p_int:  0.970125264
p_ni:  0.029874732
p_wrong:  4e-9
Data Source:  BioPlex
CDH13
Tbio
Novelty:  0.00389516
p_int:  0.968107069
p_ni:  0.031892931
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
61
hair color
1
2
0
1.2
58.9
blood metabolite measurement
1
1
1
40.4
amino acid measurement
1
1
1
40.4
protein measurement
1
1
1
40.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
61
hair color
0
1.2
58.9
blood metabolite measurement
1
40.4
amino acid measurement
1
40.4
protein measurement
1
40.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum metallopeptidase 1
VGNC:4685
464983
Macaque
endoplasmic reticulum metallopeptidase 1
717415
Mouse
MGI:106250
226090
Rat
RGD:727831
373544
Dog
endoplasmic reticulum metallopeptidase 1
VGNC:40463
484188
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum metallopeptidase 1
Macaque
endoplasmic reticulum metallopeptidase 1
Mouse
Rat
Dog
endoplasmic reticulum metallopeptidase 1
Publication Statistics
PubMed Score 8.02
PubMed score by year
PubTator Score 0.68
PubTator score by year
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Related Publications
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PMID
Year
Title