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Tbio
ERLIN2
Erlin-2

Protein Summary
Description
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618). This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276461
  • ENSP00000276461
  • ENSG00000147475
  • ENST00000335171
  • ENSP00000335220
  • ENST00000397228
  • ENSP00000380405
  • ENST00000518586
  • ENSP00000427847
  • ENST00000519638
  • ENSP00000428112
  • ENST00000523107
  • ENSP00000473292
  • ENST00000523887
  • ENSP00000429903
  • ENST00000648919
  • ENSP00000497100

Symbol
  • C8orf2
  • SPFH2
  • NET32
  • SPFH2
  • SPG18
  • C8orf2
  • Erlin-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.97
transcription factor perturbation
0.96
microRNA
0.91
transcription factor binding site profile
0.84


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.11   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.11   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (150)
GSTM5
Tbio
Family:  Enzyme
Novelty:  0.03763535
p_int:  0.999404135
p_ni:  0.000595865
Score:  0.232
Data Source:  BioPlex,STRINGDB
FKBP14
Tbio
Family:  Enzyme
Novelty:  0.02742616
p_int:  0.997639124
p_ni:  0.002308611
p_wrong:  0.000052266
Score:  0.163
Data Source:  BioPlex,STRINGDB
DUSP3
Tchem
Family:  Enzyme
Novelty:  0.00518547
p_int:  0.985612714
p_ni:  0.014387286
Score:  0.424
Data Source:  BioPlex,STRINGDB
RIC3
Tbio
Novelty:  0.0162412
p_int:  0.956948274
p_ni:  0.043051726
Score:  0.175
Data Source:  BioPlex,STRINGDB
RNF170
Tbio
Family:  Enzyme
Novelty:  0.1117879
p_int:  0.945867631
p_ni:  0.054132369
Score:  0.741
Data Source:  BioPlex,STRINGDB
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.906830135
p_ni:  0.016513721
p_wrong:  0.076656144
Score:  0.16
Data Source:  BioPlex,STRINGDB
GALNS
Tbio
Family:  Enzyme
Novelty:  0.00510529
p_int:  0.891673252
p_ni:  0.108326748
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.856305116
p_ni:  0.143694884
Score:  0.292
Data Source:  BioPlex,STRINGDB
CACNA2D1
Tclin
Family:  IC
Novelty:  0.01744541
p_int:  0.838974166
p_ni:  0.161025801
p_wrong:  3.3e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
TMUB2
Tdark
Novelty:  1.76302035
p_int:  0.817164141
p_ni:  0.182835859
Score:  0.189
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
Defective CFTR causes cystic fibrosis
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
Defective CFTR causes cystic fibrosis
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
24.5
testosterone measurement
1
1
1
9.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
24.5
testosterone measurement
1
9.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ER lipid raft associated 2
VGNC:12002
464112
Macaque
ER lipid raft associated 2
698126
Mouse
MGI:2387215
244373
Rat
RGD:1309010
290823
Dog
ER lipid raft associated 2
VGNC:40460
607518
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ER lipid raft associated 2
Macaque
ER lipid raft associated 2
Mouse
Rat
Dog
ER lipid raft associated 2
Publication Statistics
PubMed Score 31.11
PubMed score by year
PubTator Score 23.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title