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Tbio
ERLEC1
Endoplasmic reticulum lectin 1

Protein Summary
Description
Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins. This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000185150
  • ENSP00000185150
  • ENSG00000068912
  • ENST00000378239
  • ENSP00000367485
  • ENST00000405123
  • ENSP00000385629

Symbol
  • C2orf30
  • XTP3TPB
  • CIM
  • HEL117
  • XTP3-B
  • C2orf30
  • CL24936
  • CL25084
  • XTP3TPB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
histone modification site profile
0.88
transcription factor perturbation
0.8
small molecule perturbation
0.68
tissue
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.53   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.53   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (129)
CNTNAP3
Tbio
Novelty:  0.22791524
p_int:  0.999220728
p_ni:  0.000779272
Score:  0.167
Data Source:  BioPlex,STRINGDB
MICA
Tbio
Novelty:  0.03965901
p_int:  0.964901913
p_ni:  0.035098087
Data Source:  BioPlex
ATF6
Tbio
Family:  TF
Novelty:  0.00149266
p_int:  0.959231743
p_ni:  0.040768257
Score:  0.345
Data Source:  BioPlex,STRINGDB
ATF6B
Tbio
Family:  TF
Novelty:  0.07061573
p_int:  0.900335626
p_ni:  0.099664372
p_wrong:  2e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
SEL1L
Tbio
Novelty:  0.01198173
Score:  0.999
Data Source:  Reactome,STRINGDB
SYVN1
Tbio
Family:  Enzyme
Novelty:  0.02216474
Score:  0.998
Data Source:  Reactome,STRINGDB
DERL2
Tbio
Novelty:  0.02479307
Score:  0.996
Data Source:  Reactome,STRINGDB
OS9
Tbio
Novelty:  0.01490339
Score:  0.99
Data Source:  STRINGDB
VCP
Tchem
Family:  Enzyme
Novelty:  0.00103317
Score:  0.977
Data Source:  Reactome,STRINGDB
DERL1
Tbio
Novelty:  0.01382722
Score:  0.965
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
Defective CFTR causes cystic fibrosis
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
Defective CFTR causes cystic fibrosis
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
83.2
reticulocyte measurement
2
2
2
79.8
hemoglobin measurement
2
2
2
79.2
hematocrit
2
1
2
71.6
lymphocyte count
2
2
2
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
83.2
reticulocyte measurement
2
79.8
hemoglobin measurement
2
79.2
hematocrit
2
71.6
lymphocyte count
2
70.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum lectin 1
VGNC:246
470375
Macaque
endoplasmic reticulum lectin 1
716460
Mouse
MGI:1914003
66753
Rat
RGD:1306508
289874
Dog
endoplasmic reticulum lectin 1
VGNC:40458
474593
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum lectin 1
Macaque
endoplasmic reticulum lectin 1
Mouse
Rat
Dog
endoplasmic reticulum lectin 1
Publication Statistics
PubMed Score 72.53
PubMed score by year
PubTator Score 39.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title