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Tbio
ERH
Enhancer of rudimentary homolog

Protein Summary
Description
May have a role in the cell cycle.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000557016
  • ENSP00000451080
  • ENSG00000100632

Symbol
  • DROER
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.94
transcription factor binding site profile
0.88
hub protein
0.82
histone modification site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.25   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.25   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (227)
FAM208B
Tdark
Novelty:  1.21420488
p_int:  0.999999957
p_ni:  4.3e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.999999799
p_ni:  2.01e-7
Score:  0.234
Data Source:  BioPlex,STRINGDB
MPHOSPH8
Tbio
Family:  Epigenetic
Novelty:  0.0534439
p_int:  0.999999369
p_ni:  6.2e-7
p_wrong:  1.1e-8
Data Source:  BioPlex
CIZ1
Tbio
Novelty:  0.03730538
p_int:  0.999998368
p_ni:  0.000001632
p_wrong:  1e-9
Score:  0.799
Data Source:  BioPlex,STRINGDB
PPHLN1
Tbio
Novelty:  0.21311177
p_int:  0.999988141
p_ni:  0.000011859
Data Source:  BioPlex
BCLAF3
Tdark
Novelty:  1.67603845
p_int:  0.999964462
p_ni:  1.9e-8
p_wrong:  0.00003552
Data Source:  BioPlex
OSBPL3
Tbio
Novelty:  0.06106368
p_int:  0.99994035
p_ni:  0.00005965
Data Source:  BioPlex
ZNF200
Tdark
Family:  TF
Novelty:  0.69520683
p_int:  0.999929851
p_ni:  3e-9
p_wrong:  0.000070146
Data Source:  BioPlex
CHTOP
Tbio
Novelty:  0.04170391
p_int:  0.999929512
p_ni:  0.000070488
Score:  0.948
Data Source:  BioPlex,STRINGDB
DROSHA
Tbio
Family:  Enzyme
Novelty:  0.00107123
p_int:  0.999757433
p_ni:  0.000242566
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
89
myeloid white cell count
1
1
1
70.2
neutrophil percentage of leukocytes
1
1
1
68.6
leukocyte count
1
1
1
61.4
lymphocyte percentage of leukocytes
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
89
myeloid white cell count
1
70.2
neutrophil percentage of leukocytes
1
68.6
leukocyte count
1
61.4
lymphocyte percentage of leukocytes
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enhancer of rudimentary homolog
VGNC:8199
452997
Macaque
ERH, mRNA splicing and mitosis factor
712507
Mouse
MGI:108089
13877
Rat
RGD:1595409
681415
Dog
ERH, mRNA splicing and mitosis factor
VGNC:40453
480371
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enhancer of rudimentary homolog
Macaque
ERH, mRNA splicing and mitosis factor
Mouse
Rat
Dog
ERH, mRNA splicing and mitosis factor
Publication Statistics
PubMed Score 137.25
PubMed score by year
PubTator Score 9.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title