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Tbio
ERCC6L
DNA excision repair protein ERCC-6-like

Protein Summary
Description
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin (PubMed:17218258). Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334463
  • ENSP00000334675
  • ENSG00000186871

Symbol
  • PICH
  • PICH
  • RAD26L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
molecular function
0.94
protein domain
0.85
histone modification site profile
0.83
interacting protein
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.11   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.11   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (278)
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
p_int:  0.999999981
p_ni:  1.9e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
SIX1
Tbio
Family:  TF
Novelty:  0.00415613
p_int:  0.999999204
p_ni:  7.59e-7
p_wrong:  3.7e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
SIX2
Tbio
Family:  TF
Novelty:  0.01046481
p_int:  0.999998721
p_ni:  0.000001279
Score:  0.165
Data Source:  BioPlex,STRINGDB
MIDN
Tbio
Novelty:  0.0730514
p_int:  0.999743394
p_ni:  0.000021413
p_wrong:  0.000235193
Score:  0.193
Data Source:  BioPlex,STRINGDB
C14orf119
Tdark
Novelty:  2.66138202
p_int:  0.999703439
p_ni:  0.000296556
p_wrong:  5e-9
Data Source:  BioPlex
MLF1
Tbio
Novelty:  0.0239522
p_int:  0.997869225
p_ni:  0.002130766
p_wrong:  9e-9
Data Source:  BioPlex
CHEK1
Tchem
Family:  Kinase
Novelty:  0.00066843
p_int:  0.995981915
p_ni:  0.004018079
p_wrong:  6e-9
Score:  0.641
Data Source:  BioPlex,STRINGDB
WDFY2
Tbio
Novelty:  0.01835759
p_int:  0.99580272
p_ni:  0.004171017
p_wrong:  0.000026264
Score:  0.216
Data Source:  BioPlex,STRINGDB
TIMM8A
Tbio
Family:  Enzyme
Novelty:  0.00954602
p_int:  0.995270171
p_ni:  0.00472771
p_wrong:  0.000002119
Data Source:  BioPlex
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.994617052
p_ni:  0.005373585
p_wrong:  0.000009363
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
54.3
sodium measurement
1
1
1
42.2
platelet crit
1
1
1
35
chloride measurement
1
1
1
33
platelet count
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
54.3
sodium measurement
1
42.2
platelet crit
1
35
chloride measurement
1
33
platelet count
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ERCC excision repair 6 like, spindle assembly checkpoint helicase
VGNC:2738
465709
Macaque
ERCC excision repair 6 like, spindle assembly checkpoint helicase
699138
Mouse
MGI:2654144
236930
Rat
RGD:1565734
317252
Dog
ERCC excision repair 6 like, spindle assembly checkpoint helicase
VGNC:54138
491955
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ERCC excision repair 6 like, spindle assembly checkpoint helicase
Macaque
ERCC excision repair 6 like, spindle assembly checkpoint helicase
Mouse
Rat
Dog
ERCC excision repair 6 like, spindle assembly checkpoint helicase
Publication Statistics
PubMed Score 68.11
PubMed score by year
PubTator Score 21.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title