Tchem ERCC5 DNA repair protein complementing XP-G cells

Protein Summary

Description

Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too. This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, cognitive disability, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• P28715
• A6NGT4
• Q5JUS4
• Q5JUS5
• Q7Z2V3
• Q8IZL6
• Q8N1B7
• Q9HD59
• Q9HD60

Gene Name

• ERCC5

Ensembl ID

• ENST00000355739
• ENSP00000347978
• ENSG00000134899
• ENST00000375954
• ENSP00000365121
• ENST00000535557
• ENSP00000442117

Symbol

• ERCM2
• XPG
• XPGC
• XPG
• UVDR
• XPGC
• COFS3
• ERCM2
• ERCC5-201

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	1
transcription factor binding site profile	0.93
protein domain	0.92
disease perturbation	0.9
molecular function	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.28   (req: < 5)

Gene RIFs: 149   (req: <= 3)

Antibodies: 331   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.28   (req: >= 5)

Gene RIFs: 149   (req: > 3)

Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0