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Tchem
ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

Protein Summary
Description
ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor acti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391945
  • ENSP00000375809
  • ENSG00000104884
  • ENST00000485403
  • ENSP00000431229

Symbol
  • XPD
  • XPDC
  • EM9
  • TTD
  • XPD
  • TTD1
  • COFS2
  • TFIIH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.99
biological term
0.99
protein domain
0.99
disease perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1120.55   (req: < 5)
Gene RIFs: 450   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1120.55   (req: >= 5)
Gene RIFs: 450   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (304)
CCNH
Tbio
Novelty:  0.00693072
p_int:  0.992986513
p_ni:  0.007013487
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDK7
Tchem
Family:  Kinase
Novelty:  0.00322814
p_int:  0.981113795
p_ni:  0.018886205
Score:  0.999
Data Source:  BioPlex,STRINGDB
MNAT1
Tbio
Family:  Enzyme
Novelty:  0.02484936
p_int:  0.823269031
p_ni:  0.176730969
Score:  0.999
Data Source:  BioPlex,STRINGDB
GTF2H3
Tbio
Novelty:  0.08168167
Score:  0.999
Data Source:  STRINGDB
GTF2H4
Tbio
Novelty:  0.03140561
Score:  0.999
Data Source:  STRINGDB
GTF2H2
Tbio
Novelty:  0.02761619
Score:  0.999
Data Source:  STRINGDB
GTF2H1
Tbio
Novelty:  0.01736328
Score:  0.999
Data Source:  STRINGDB
ERCC3
Tbio
Family:  Enzyme
Novelty:  0.00978601
Score:  0.999
Data Source:  STRINGDB
ERCC5
Tchem
Family:  Enzyme
Novelty:  0.00819696
Score:  0.999
Data Source:  STRINGDB
GTF2H5
Tbio
Novelty:  0.03493285
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (58)
Cytosolic iron-sulfur cluster assembly (R-HSA-2564830)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 49
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic iron-sulfur cluster assembly
Reactome
DNA Repair
Reactome
Disease
Reactome
Dual Incision in GG-NER
Reactome
Dual incision in TC-NER
Name
Explore in Pharos
Explore in Source
Cytosolic iron-sulfur cluster assembly
DNA Repair
Disease
Dual Incision in GG-NER
Dual incision in TC-NER
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (64)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
4
4
7
98.4
heel bone mineral density
2
3
4
89.9
apolipoprotein B measurement
1
6
6
87.1
platelet crit
1
1
1
85.3
leukocyte count
1
1
1
82.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
7
98.4
heel bone mineral density
4
89.9
apolipoprotein B measurement
6
87.1
platelet crit
1
85.3
leukocyte count
1
82.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ERCC excision repair 2, TFIIH core complex helicase subunit
VGNC:7479
456124
Macaque
ERCC excision repair 2, TFIIH core complex helicase subunit
715485
Mouse
MGI:95413
13871
Rat
RGD:1309109
308415
Dog
ERCC excision repair 2, TFIIH core complex helicase subunit
VGNC:40442
493995
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ERCC excision repair 2, TFIIH core complex helicase subunit
Macaque
ERCC excision repair 2, TFIIH core complex helicase subunit
Mouse
Rat
Dog
ERCC excision repair 2, TFIIH core complex helicase subunit
Publication Statistics
PubMed Score 1120.55
PubMed score by year
PubTator Score 765.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title