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Tbio
ERCC1
DNA excision repair protein ERCC-1

Protein Summary
Description
Isoform 1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000013807
  • ENSP00000013807
  • ENSG00000012061
  • ENST00000300853
  • ENSP00000300853
  • ENST00000340192
  • ENSP00000345203
  • ENST00000423698
  • ENSP00000394875
  • ENST00000589165
  • ENSP00000468035

Symbol
  • UV20
  • COFS4
  • RAD10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
disease perturbation
0.96
kinase perturbation
0.96
transcription factor perturbation
0.94
biological process
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1430.47   (req: < 5)
Gene RIFs: 463   (req: <= 3)
Antibodies: 1117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1430.47   (req: >= 5)
Gene RIFs: 463   (req: > 3)
Antibodies: 1117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0