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Tbio
ERC1
ELKS/Rab6-interacting/CAST family member 1

Protein Summary
Description
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347735
  • ENSP00000340054
  • ENSG00000082805
  • ENST00000360905
  • ENSP00000354158
  • ENST00000397203
  • ENSP00000380386
  • ENST00000440394
  • ENSP00000410064
  • ENST00000543086
  • ENSP00000438546
  • ENST00000545948
  • ENSP00000442976
  • ENST00000589028
  • ENSP00000468263
  • ENST00000611180
  • ENSP00000479523
  • ENST00000634346
  • ENSP00000489059
  • ENSG00000283017
  • ENST00000634945
  • ENSP00000489460
  • ENST00000635106
  • ENSP00000489601
  • ENST00000635345
  • ENSP00000489265
  • ENST00000635430
  • ENSP00000489361
  • ENST00000635459
  • ENSP00000489064
  • ENST00000635644
  • ENSP00000489120
  • ENST00000635703
  • ENSP00000489206

Symbol
  • ELKS
  • KIAA1081
  • RAB6IP2
  • ELKS
  • Cast2
  • ERC-1
  • RAB6IP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
transcription factor perturbation
0.96
histone modification site profile
0.88
trait
0.86
microRNA
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.19   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.19   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.999999935
p_ni:  6.3e-8
p_wrong:  2e-9
Data Source:  BioPlex
TSHB
Tbio
Novelty:  0.00194403
p_int:  0.999999923
p_ni:  7.4e-8
p_wrong:  3e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
SPERT
Tbio
Novelty:  0.12255061
p_int:  0.999999447
p_ni:  5.48e-7
p_wrong:  5e-9
Score:  0.199
Data Source:  BioPlex,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.999938914
p_ni:  0.000061082
p_wrong:  5e-9
Data Source:  BioPlex
GFOD1
Tdark
Family:  Enzyme
Novelty:  0.35031766
p_int:  0.999760784
p_ni:  0.000235534
p_wrong:  0.000003682
Score:  0.209
Data Source:  BioPlex,STRINGDB
MFAP4
Tbio
Novelty:  0.02023782
p_int:  0.999353185
p_ni:  0.000646516
p_wrong:  2.99e-7
Data Source:  BioPlex
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
Score:  0.968
Data Source:  STRINGDB
CHUK
Tchem
Family:  Kinase
Novelty:  0.00151532
Score:  0.954
Data Source:  STRINGDB
NFKBIA
Tchem
Novelty:  0.00022873
Score:  0.954
Data Source:  STRINGDB
IKBKB
Tchem
Family:  Kinase
Novelty:  0.00090202
Score:  0.953
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
7
15
98.4
bone density
2
2
2
57
systolic blood pressure
1
1
1
53.7
reticulocyte measurement
2
1
2
49.5
mean corpuscular hemoglobin concentration
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
15
98.4
bone density
2
57
systolic blood pressure
1
53.7
reticulocyte measurement
2
49.5
mean corpuscular hemoglobin concentration
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ELKS/RAB6-interacting/CAST family member 1
VGNC:8596
451740
Mouse
MGI:2151013
111173
Rat
RGD:628733
266806
Dog
ELKS/RAB6-interacting/CAST family member 1
VGNC:40439
486753
Horse
ELKS/RAB6-interacting/CAST family member 1
VGNC:17653
100050184
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ELKS/RAB6-interacting/CAST family member 1
Mouse
Rat
Dog
ELKS/RAB6-interacting/CAST family member 1
Horse
ELKS/RAB6-interacting/CAST family member 1
Publication Statistics
PubMed Score 79.19
PubMed score by year
PubTator Score 17.68
PubTator score by year
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Related Publications
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PMID
Year
Title