You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ERC1
ELKS/Rab6-interacting/CAST family member 1

Protein Summary
Description
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347735
  • ENSP00000340054
  • ENSG00000082805
  • ENST00000360905
  • ENSP00000354158
  • ENST00000397203
  • ENSP00000380386
  • ENST00000440394
  • ENSP00000410064
  • ENST00000543086
  • ENSP00000438546
  • ENST00000545948
  • ENSP00000442976
  • ENST00000589028
  • ENSP00000468263
  • ENST00000611180
  • ENSP00000479523
  • ENST00000634346
  • ENSP00000489059
  • ENSG00000283017
  • ENST00000634945
  • ENSP00000489460
  • ENST00000635106
  • ENSP00000489601
  • ENST00000635345
  • ENSP00000489265
  • ENST00000635430
  • ENSP00000489361
  • ENST00000635459
  • ENSP00000489064
  • ENST00000635644
  • ENSP00000489120
  • ENST00000635703
  • ENSP00000489206

Symbol
  • ELKS
  • KIAA1081
  • RAB6IP2
  • ELKS
  • Cast2
  • ERC-1
  • RAB6IP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
transcription factor perturbation
0.96
histone modification site profile
0.88
trait
0.86
microRNA
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.65   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.65   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0