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Tclin
ERBB3
Receptor tyrosine-protein kinase erbB-3

Protein Summary
Description
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267101
  • ENSP00000267101
  • ENSG00000065361
  • ENST00000411731
  • ENSP00000415753
  • ENST00000415288
  • ENSP00000408340
  • ENST00000551242
  • ENSP00000447510

Symbol
  • HER3
  • HER3
  • FERLK
  • LCCS2
  • ErbB-3
  • c-erbB3
  • erbB3-S
  • MDA-BF-1
  • c-erbB-3
  • p180-ErbB3
  • p45-sErbB3
  • p85-sErbB3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.99
transcription factor perturbation
0.98
hub protein
0.97
kinase perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1060.37   (req: < 5)
Gene RIFs: 342   (req: <= 3)
Antibodies: 2081   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1060.37   (req: >= 5)
Gene RIFs: 342   (req: > 3)
Antibodies: 2081   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (258)
P10314
Tbio
Novelty:  0.00270731
p_int:  0.965650226
p_ni:  0.034349773
Score:  0.367
Data Source:  BioPlex,STRINGDB
UQCRH
Tbio
Novelty:  0.04494433
p_int:  0.939955803
p_ni:  0.002908501
p_wrong:  0.057135696
Score:  0.173
Data Source:  BioPlex,STRINGDB
SLC31A1
Tbio
Family:  Transporter
Novelty:  0.00658529
p_int:  0.932496876
p_ni:  0.067502664
p_wrong:  4.6e-7
Score:  0.234
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.924464822
p_ni:  0.075535178
Data Source:  BioPlex
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.900799999
p_ni:  0.072877564
p_wrong:  0.026322437
Data Source:  BioPlex
PDF
Tchem
Family:  Enzyme
Novelty:  0.02477934
p_int:  0.793658535
p_ni:  0.206341465
p_wrong:  1e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.764674375
p_ni:  0.235325625
Data Source:  BioPlex
NRG1
Tbio
Novelty:  0.00095246
Score:  0.997
Data Source:  Reactome,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.994
Data Source:  Reactome,STRINGDB
NRG2
Tbio
Novelty:  0.01986994
Score:  0.993
Data Source:  Reactome,STRINGDB
Pathways (66)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

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Find Similar Targets
Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downregulation of ERBB2 signaling
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Downregulation of ERBB2 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (51)
Find Similar Targets
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (48)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
7
6
6
3.4
97.2
6
5
0
1.3
95.2
mathematical ability
4
4
4
94.3
8
7
0
1.1
93.3
3
3
0
1.3
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
3.4
97.2
0
1.3
95.2
mathematical ability
4
94.3
0
1.1
93.3
0
1.3
91.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
erb-b2 receptor tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:3431]
Mouse
MGI:95411
13867
Rat
RGD:69323
29496
Dog
erb-b2 receptor tyrosine kinase 3
VGNC:54147
481105
Horse
erb-b2 receptor tyrosine kinase 3
VGNC:17650
100059216
Species
Name
OMA
EggNOG
Inparanoid
Macaque
erb-b2 receptor tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:3431]
Mouse
Rat
Dog
erb-b2 receptor tyrosine kinase 3
Horse
erb-b2 receptor tyrosine kinase 3
Publication Statistics
PubMed Score 1060.37
PubMed score by year
PubTator Score 864.45
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title