Tchem ERAP1 Endoplasmic reticulum aminopeptidase 1

Protein Summary

Description

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• Q9NZ08
• O60278
• Q6UWY6
• Q8NEL4
• Q8TAD0
• Q9UHF8
• Q9UKY2

Gene Name

• ERAP1

Ensembl ID

• ENST00000296754
• ENSP00000296754
• ENSG00000164307
• ENST00000443439
• ENSP00000406304

Symbol

• APPILS
• ARTS1
• KIAA0525
• ALAP
• A-LAP
• ARTS1
• ERAAP
• APPILS
• ARTS-1
• ERAAP1
• PILSAP
• PILS-AP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
transcription factor perturbation	0.98
cellular component	0.81
biological term	0.76
histone modification site profile	0.76

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Endoplasmic Reticulum Aminopeptidase 1

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Endoplasmic Reticulum Aminopeptidase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.44   (req: < 5)

Gene RIFs: 196   (req: <= 3)

Antibodies: 312   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.44   (req: >= 5)

Gene RIFs: 196   (req: > 3)

Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 39

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0